EFSA被要求对食品中N-亚硝基化合物（N-NA）存在与公共健康风险相关的科学意见。风险评估仅限于食品中存在的10种致癌性N-NA（TCNA），即NDMA、NMEA、NDEA、NDPA、NDBA、NMA、NSAR、NMOR、NPIP和NPYR。N-NA具有基因毒性并可导致啮齿动物肝肿瘤。推导效能因子可用的现场数据有限，因此假定TCNA具有相等的效能。基准剂量下限的10%（BMDL10）为10μg/kg体重（bw）·每天，来自NDEA诱导大鼠肝肿瘤（良性和恶性）的发生率，并采用毒性外部边际（MOE）方法。N-NA的发生分析结果从EFSA发生数据库（n=2,817）和文献（n=4,003）中提取。发生数据适用于涵盖TCNA的五个食品类别。对两种情形进行了膳食暴露评估，排除（情形1）和包括（情形2）熟制未加工的肉类和鱼类。TCNA的暴露范围从各项调查中的0到208.9 ng/kg bw每天不等。 “肉和肉制品”是导致TCNA暴露的主要食品类别。在不包括一些婴儿调查P95暴露等于零的情况下，MOE在P95暴露中范围从3,337至48。两个主要不确定性是（i）高数目的左修剪数据和（ii）缺乏重要食品类别的数据。 CONTAM小组得出结论，对于所有年龄组而言，在P95暴露下，TCNA的MOE极有可能（98-100％确定）小于10,000，这引起了健康担忧。©2023年欧洲食品安全局。由Wiley‐VCH GmbH代表欧洲食品安全局出版的EFSA期刊。

EFSA was asked for a scientific opinion on the risks to public health related to the presence of N-nitrosamines (N-NAs) in food. The risk assessment was confined to those 10 carcinogenic N-NAs occurring in food (TCNAs), i.e. NDMA, NMEA, NDEA, NDPA, NDBA, NMA, NSAR, NMOR, NPIP and NPYR. N-NAs are genotoxic and induce liver tumours in rodents. The in vivo data available to derive potency factors are limited, and therefore, equal potency of TCNAs was assumed. The lower confidence limit of the benchmark dose at 10% (BMDL10) was 10 μg/kg body weight (bw) per day, derived from the incidence of rat liver tumours (benign and malignant) induced by NDEA and used in a margin of exposure (MOE) approach. Analytical results on the occurrence of N-NAs were extracted from the EFSA occurrence database (n = 2,817) and the literature (n = 4,003). Occurrence data were available for five food categories across TCNAs. Dietary exposure was assessed for two scenarios, excluding (scenario 1) and including (scenario 2) cooked unprocessed meat and fish. TCNAs exposure ranged from 0 to 208.9 ng/kg bw per day across surveys, age groups and scenarios. 'Meat and meat products' is the main food category contributing to TCNA exposure. MOEs ranged from 3,337 to 48 at the P95 exposure excluding some infant surveys with P95 exposure equal to zero. Two major uncertainties were (i) the high number of left censored data and (ii) the lack of data on important food categories. The CONTAM Panel concluded that the MOE for TCNAs at the P95 exposure is highly likely (98-100% certain) to be less than 10,000 for all age groups, which raises a health concern.© 2023 European Food Safety Authority. EFSA Journal published by Wiley‐VCH GmbH on behalf of European Food Safety Authority.