评估在意大利，15至16岁时首批接种疫苗的女孩的第一批队列中，人乳头瘤病毒疫苗接种状态与25岁时参与宫颈癌筛查的关联。在2018年至2020年间，1993年、1994年和1995年出生的女性被邀请参加宫颈癌筛查。我们报告了弗洛伦萨、皮埃蒙特和萨沃纳等三个大区，共有参加筛查的女性，并按接种状态进行分类。估计了接种（≥2剂）和未接种女性的参与风险。通过逻辑回归，调整了出生地和出生队列，估算了疫苗接种状态的参与度的比值比（OR）。总体而言，有34,993名女性被邀请进行筛查：13,006名（37.2％）参加了筛查，其中10,062名同意参加共识干预研究。在受邀和筛查参与者中，分别有51.0％和60.6％的接种者。对比接种和未接种女性，在整体、弗洛伦萨、皮埃蒙特和萨沃纳等地区，参与筛查的调整OR分别为1.80（95％置信区间（CI）：1.72-1.89）、2.17（95％CI：1.94-2.42）、1.59（95％CI：1.50-1.68）和1.15（95％CI：0.86-1.54）。受邀女性中约33％未接种且未参与筛查：分别为25.8％、59.5％和64.2％的在意大利、受高移民压力的国家和先进发展国家出生的女性。接种疫苗的女性参与筛查的比例高于未接种的女性。需要采取积极政策，以缩小不平等，重点针对未筛查和未接种人群，特别是非本地女性，加速意大利的宫颈癌消除。

To evaluate the association between human papillomavirus vaccination status and participation in cervical cancer screening (at age 25) by the first cohorts of girls who were offered vaccination at the age of 15 to 16 years in Italy.Women born in 1993, 1994 and 1995 were invited to participate in cervical cancer screening between 2018 and 2020. We report participation in screening by vaccination status in three large areas, Florence province, Piedmont region and Savona province, where the Consensus Project was carried out. The relative risk of participation among vaccinated (≥2 doses) and unvaccinated women was estimated. Odds ratios (OR) of participation by vaccination status were estimated by logistic regression, adjusted by birthplace and birth cohort.Overall, 34,993 women were invited for screening: 13,006 (37.2%) participated and 10,062 of these agreed to participate in the Consensus intervention study. Among the invited women and screening participants, vaccinated women were 51.0% and 60.6%, respectively. Comparing vaccinated and unvaccinated women, the adjusted OR of screening participation was 1.80 (95% confidence interval (CI): 1.72-1.89), 2.17 (95% CI: 1.94-2.42), 1.59 (95% CI: 1.50-1.68) and 1.15 (95% CI: 0.86-1.54) for overall, Florence, Piedmont and Savona, respectively. About 33% of the invited women were unvaccinated and did not participate in screening: 25.8%, 59.5% and 64.2% of women born in Italy, in high migration pressure countries and in advanced development countries, respectively.Screening participation was higher among vaccinated than unvaccinated women. Active policies are needed to reduce inequalities, targeting the unscreened and unvaccinated population, particularly non-native women, to accelerate cervical cancer elimination in Italy.