单克隆球蛋白病是一组与浆细胞克隆增殖产生单克隆蛋白相关的疾病。本研究的主要目标是描述在19年间在摩洛哥教学医院诊断的单克隆球蛋白病的流行病学和免疫化学特征。这项回顾性研究在马耳他首都拉巴特军医院生化科收集了满足纳入和排除标准的443名单克隆球蛋白病患者，其中320名（72.23%）为男性，123名（27.77%）为女性。所有患者都来自摩洛哥的12个地区，样本经过血清蛋白电泳和血清免疫固定电泳进一步表征单克隆蛋白。443名参与者的平均年龄为62.24±13.14岁，住院原因包括骨痛（41.60%）、肾功能衰竭（19.08%）、全身状况改变（12.21%）和贫血（10.69%）。我们研究中的浆细胞增殖性疾病包括多发性骨髓瘤（MM）（45.65%）、未确定意义的单克隆球蛋白病（MGUS）（39.05%）、华氏巨球蛋白血症（5.58%）、淋巴瘤（2.27%+1.2%）、慢性淋巴细胞性白血病（2.48%）、浆细胞白血病（1.86%）、浆细胞瘤（0.62%）、POEMS综合征（0.41%）和淀粉样变性（0.84%）。在MM中最常见的亚型是IgGκ（62例，36.5%）、IgGλ（52例，30.6%）、IgAκ（27例，15.9%）和IgAλ（19例，11.2%）。值得注意的是，自由轻链MM占所有MM病例的20%。我们发现单克隆球蛋白病与年龄相关，男性比女性更容易受到影响，该研究结果还指出单克隆球蛋白病的延迟诊断，因为我们的大多数患者是在MM阶段被诊断出来的。在MM和MGUS中最常见的亚型是IgGκ和IgGλ，在华氏巨球蛋白血症中是IgMκ和IgMλ，寡克隆谱仅占3.70%。©2023 Wiley Periodicals LLC出版的癌症报告。

Monoclonal gammopathies are a group of disorders associated with clonal proliferation of plasma cells that produces a monoclonal protein.The main objective of this study was to describe the epidemiological and immunochemical characteristics of monoclonal gammopathies diagnosed during 19 years in a Moroccan teaching hospital.This retrospective study enrolled 443 Moroccan patients with monoclonal gammopathy, patients meeting the inclusion and exclusion criteria in at the biochemistry department of Military Hospital in Rabat, the capital of Morocco, from January 2000 to August 2019. Of the 443 enrolled patients, 320 (72.23%) were men and 123 (27.77%) were women. All patients were of Caucasian origin, from 12 Moroccan regions. The patient's samples were collected and subjected to serum protein electrophoresis and serum immunofixation electrophoresis to further characterize the monoclonal protein. The mean ± SD age of the 443 participants was 62.24 ± 13.14 years. Reasons for being admitted to the hospital were as follows, bone pain (41.60%), renal failure (19.08%), alteration of the general condition (12.21%), and anemia (10.69). Plasma cell proliferative disorders in our study were as follows, multiple myeloma (MM) (45.65%), Monoclonal gammopathies of undetermined significance (MGUS) (39.05%), Waldenstrom's macroglobulinemia (5.58%), Lymphoma (2.27% + 1.2%), Chronic Lymphocytic Leukemia (2.48%), Plasma cell leukemia (1.86%), Plasmacytoma (0.62%), POEMS syndrome (0.41%), and Amyloidosis (0.84%). The most frequent isotypes in MM were the IgGκ (62) 36.5%, IgGλ (52) 30.6%, IgAκ (27) 15.9%, and the IgAλ (19) 11.2%. It is also worth noting that Free light chain MM represents 20% of all cases of MM.We found that monoclonal gammopathies are age-related and affects men more than women, also the results of this study point to the delayed diagnosis of monoclonal gammopathies, since most of our patients were diagnosed at the MM stage. The most frequent isotypes were the IgGκ and IgGλ in MM and MGUS, in Waldenström macroglobulinemia were IgMκ and IgMλ and the oligoclonal profile represented only 3.70%.© 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC.