这篇系统性综述的目的是评价和分析复杂性区域性疼痛综合症1（CRPS 1）中与骨相关的生化和组织学生物标记物的知识。共分析了7项研究（生化分析n = 3，动物研究n = 1，组织学检查n = 3）。两项研究被归类为低风险偏倚，五项研究被归类为中等风险偏倚。生化分析表明，在增加骨吸收（脱氧吡啶醇尿液水平升高）和骨形成（降钙素，骨髓网蛋白和碱性磷酸酶血清水平升高）的同时，骨代谢有所增加。动物研究报告了骨折后四周前炎性肿瘤坏死因子的信号增加，但并没有促使局部骨质流失。从活检中的组织学检查中发现，急性CRPS 1中皮质骨变薄和吸收，髓质骨稀疏和减少以及骨髓血管变化，慢性CRPS 1中骨髓被发育不良的血管替代。有限的数据揭示了CRPS中某些具有潜力的与骨有关的生物标志物。生物标志物有潜力发现可能从影响骨代谢的治疗中获益的患者。因此，这篇综述确定了CRPS 1患者未来研究的重要领域。本文受版权保护，所有权利均受保护。

The aim of this systematic review was to appraise and analyze the knowledge on bone-related biochemical and histological biomarkers in Complex Regional Pain Syndrome 1 (CRPS 1). A total of 7 studies were included in the analysis (biochemical analyses n=3, animal study n=1, histological examination n=3). Two studies were classified as having low risk of bias and five studies with a moderate risk of bias. Biochemical analysis indicated an increased bone turnover with increased bone resorption (elevated urinary levels of deoxypyridinoline) and bone formation (increased serum levels of calcitonin, osteoprotegrin and alkaline phosphatase). The animal study reported an increased signaling of proinflammatory tumor necrosis factor four weeks post-fracture, which did however not contribute to local bone loss. Histological examination from biopsies revealed thinning and resorption of cortical bone, rarefication and reduction of trabecular bone and vascular modification in the bone marrow in acute CRPS 1 and replacement of the bone marrow by dystrophic vessels in chronic CRPS 1. The limited data reviewed revealed certain potential bone-related biomarkers in CRPS. Biomarkers hold the potential to identify patients that may benefit from treatments that influence bone turnover. Thus, this review identifies important areas for future research in CRPS1 patients.This article is protected by copyright. All rights reserved.