哺乳动物雷帕霉素(mTOR)通路的作用是对动物生长进行实际营养敏感性调节，并在生理学、代谢和常见疾病中发挥核心作用。mTOR会在接收到营养、生长因子和细胞能量的情况下被激活。mTOR通路会激活各种细胞过程和人类癌症疾病。mTOR信号传导功能失调与代谢紊乱和癌症等疾病相关联。近年来，开发靶向癌症的药物取得了重大成就。癌症的全球影响仍在增长。然而，疾病修正治疗的重点仍然难以确定。mTOR是癌症中的一个重要靶点，虽然成本很高，但是需要考虑使用mTOR抑制剂。尽管有许多mTOR抑制剂，但是专门针对mTOR的强效、选择性抑制剂仍然很少。因此，在本综述中，我们将讨论mTOR的结构和蛋白质配体相互作用，为分子建模和基于结构的药物设计提供基础。本文介绍了mTOR、其晶体结构以及最新的mTOR研究。此外，本文还回顾了mTOR在癌症中的作用、功能和调节机制。此外，还探讨了mTOR信号传导网络在癌症中的机制角色和与抑制mTOR发展的药物的相互作用，以及mTOR和其复合物的晶体结构。最后，本文将讨论mTOR靶向治疗的现状和前景。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至epub@benthamscience.net。

The mammalian role of the rapamycin (mTOR) pathway is the practical nutrient-sensitive regulation of animal growth and plays a central role in physiology, metabolism, and common diseases. The mTOR is activated in response to nutrients, growth factors, and cellular energy. The mTOR pathway activates in various cellular processes and human cancer diseases. Dysfunction of mTOR signal transduction is associated with metabolic disorders, cancer for instance.In recent years, significant achievements envisaged in developing targeted drugs for cancer. The global impact of cancer continues to grow. However, the focus of disease-modifying therapies remains elusive. The mTOR is a significant target in cancer to be considered for mTOR inhibitors, even though the costs are high. Despite many mTOR inhibitors, potent, selective inhibitors for mTOR are still limited. Therefore, in this review, the mTOR structure and protein-ligand interactions of utmost importance to provide the basis for molecular modelling and structure-based drug design are discussed.This review introduces the mTOR, its crystal structure, and the latest research on mTOR.Besides, the role of mTOR in cancer, its function, and its regulation are reviewed. In addition, the mechanistic role of mTOR signalling networks in cancer and interaction with drugs that inhibit the development of mTOR and crystal structures of mTOR and its complexes are explored. Finally, the current status and prospects of mTOR-targeted therapy are addressed.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.