全球使用肿瘤学药物的增加以及这些药品更高的价格，引发了如何降低这些成本的问题。降低成本的一种方式是通过保存瓶中（昂贵的）肿瘤学药物的残留物，延长超出使用日期来减少溢出量，而不是浪费。因此，我们调查了是否可以使用普通的针头代替昂贵的封闭系统转移装置，在常温和冰箱温度下，延长药物的超出使用日期，在重新构成和部分液体抽取药瓶后的七天内。共有600个含有高浓度胰蛋白胨的瓶子，加入10毫升0.9%氯化钠，然后使用普通针头或MicroSpike刺破其中300个，约取出3毫升并丢弃。然后，将这些瓶子存放在冰箱或室温下七天。七天后，将这600个瓶子运输并在30°C至35°C的温度下孵育14天。在七天内存放在室温或冰箱中以及两周的孵育后，所有600个瓶子都没有被污染，无论是使用MicroSpike针头还是普通针头刺破。总之，医院药房在尽可能降低肿瘤学药物高昂成本方面发挥着重要作用。此研究表明，使用针头而不是更昂贵的封闭系统转移装置来保存剩余的肿瘤学药物将进一步减少昂贵药物的溢出，从而降低医疗保健成本。 Copyright© by International Journal of Pharmaceutical Compounding, Inc.

The global increase of use of oncology drugs combined with the higher costs of these drugs raise the question of how to reduce these costs. One way to reduce the costs is to reduce spillage by extending the beyond-use date by preserving remainders in the vial of (expensive) oncology drugs instead of wasting them. Therefore, we investigated if spikes, instead of the expensive closed-system transfer devices, can be used to extend the beyond-use date of drugs both at room temperature and in the refrigerator during seven days after reconstitution and partial fluid withdrawal of a vial. Six hundred vials containing concentrated tryptic soy broth were reconstituted with 10-mL of sodium chloride 0.9%, after which approximately 3 mL were removed from the vial and discarded using a regular spike for 300 vials and a MicroSpike for the other 300 vials. Subsequently, the vials were stored either at refrigerator temperature or at room temperature for seven days. After seven days, all six hundred vials were transported and incubated at a temperature of 30°C to 35°C for fourteen days. None of the six hundred vials used showed contamination, either punctured with a MicroSpike or with a regular spike, after storage of seven days at room temperature or in the refrigerator and two weeks of incubation. Conclusively, it can be stated that hospital pharmacies play an important role in keeping the high costs of oncology drugs as low as possible. This study shows that using a spike instead of a more expensive closed-system transfer device for preservation of the remainder of oncology drugs will further reduce spillage of expensive drugs resulting in lower healthcare costs.Copyright© by International Journal of Pharmaceutical Compounding, Inc.