视网膜母细胞瘤（RB）是婴幼儿常见的癌症。这是一种可治愈的疾病，然而，延迟诊断或治疗使治疗变得困难。基因突变在RB的发病机制中起着关键作用。像RNA（编码和非编码RNA）这样的基因物质也参与了肿瘤的进展。循环RNA（circRNA）是最近发现的RNA，主要通过“微小RNA海绵”来调节基因表达。circRNA的失调已在多种疾病和肿瘤中观察到。另外，各种研究表明circRNA的表达在RB组织中发生了改变。由于circRNA在疾病发病机制中的作用，它们可能对RB患者作为诊断或预后生物标记物有所帮助。此外，circRNA可能是治疗RB的适当治疗靶点，可以采用靶向治疗方法。©2023。作者（S）独家授权给西班牙肿瘤学联合会（FESEO）。

Retinoblastoma (RB) is a common cancer in infants and children. It is a curable disease; however, a delayed diagnosis or treatment makes the treatment difficult. Genetic mutations have a central role in the pathogenesis of RB. Genetic materials such as RNAs (coding and non-coding RNAs) are also involved in the progression of the tumor. Circular RNA (circRNA) is the most recently identified RNA and is involved in regulating gene expression mainly through "microRNA sponges". The dysregulation of circRNAs has been observed in several diseases and tumors. Also, various studies have shown that circRNAs expression is changed in RB tissues. Due to their role in the pathogenesis of the disease, circRNAs might be helpful as a diagnostic or prognostic biomarker in patients with RB. In addition, circRNAs could be a suitable therapeutic target to treat RB in a targeted therapy approach.© 2023. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).