基于共轭聚合物和巨噬细胞负载的水凝胶的生物光子学装置，用于触发免疫疗法。
A biophotonic device based on a conjugated polymer and a macrophage-laden hydrogel for triggering immunotherapy.
发表日期：2023 Mar 31
作者：
Zhiwen Yang, Qi Shen, Longjiang Xing, Xuancheng Fu, Zhipeng Qiu, Hongping Xiang, Yiming Huang, Fengting Lv, Haotian Bai, Yanping Huo, Shu Wang
来源：
CYTOKINE & GROWTH FACTOR REVIEWS
摘要：
采用三维打印技术制造基于生物光子的设备，用于肿瘤免疫治疗。该设备采用柔性的有机发光二极管（OLED），具有深蓝色发光特性，以及含有聚苯乙烯乙烯（PPV）衍生物和巨噬细胞（M0-RAW264.7）的明胶-海藻酸盐水凝胶。OLED激发PPV产生反应性氧自由基（ROS），使巨噬细胞极化为M1表型，分泌细胞毒性细胞因子，诱导肿瘤细胞凋亡。这种策略为制造涉及细胞的生物光子设备提供了一种新方法，用于免疫治疗。
A biophotonic device is fabricated by a 3D printing technique for tumor immunotherapy utilizing a flexible organic light-emitting diode (OLED) with deep blue emission and a gelatin-alginate hydrogel that contains a poly(phenylene vinylene) (PPV) derivative and live immune cells of macrophages (M0-RAW264.7). PPV is excited by the OLED to generate reactive oxygen species (ROS), enabling the macrophages to polarize to the M1 phenotype and secrete cytotoxic cytokines to induce the apoptosis of tumor cells. This strategy provides a new method for fabricating cell-involved biophotonic devices for immunotherapy.