因为更先进的癌症治疗，乳腺癌幸存者的寿命更长；然而，心血管疾病（CVD）是乳腺癌幸存者的主要非癌症死因。以前的研究表明，抑郁症与CVD发展风险增加有关。本研究调查了抑郁症状或情感障碍史，无论是独立还是与心脏毒性治疗相结合，是否预测了乳腺癌幸存者使用一种新指标——基于运动负荷试验的年龄（ABEST）指数的老年心肺年龄。乳腺癌幸存者（N = 80，年龄26-72岁，I-IIIA期）平均在手术后53天（SD = 26）接受评估，但在辅助治疗之前，并于平均32个月（SD = 6）后再次接受评估。在两次访问中，他们使用流行病学中心抑郁症量表（CES-D）报告抑郁症状，完成了DSM-V结构化临床访谈，并进行运动负荷试验以获得ABEST分数。在控制治疗类型、年龄、教育、躯干脂肪、抗抑郁药物使用和两次访问之间的时间的情况下，纵向分析显示，与没有这种历史的同龄人相比，有情感障碍史的乳腺癌幸存者ABEST分数随着时间的推移而恶化（p = .046）。 1和2之间的身体活动变化没有调节这种关系（95％CI：-0.16-0.51）。辅助分析为主要发现提供了一些额外的支持，例如那些有情感障碍史的人倾向于出现更大的Vo2max下降，尽管结果在统计上具有边际性的非显著性（p = .095）。抑郁症状或情感障碍史与ABEST分数之间没有交叉分析关系（ps> .20）。治疗类型未调节观察到的关系（ps> .22）。有情感障碍史的乳腺癌幸存者可能会比没有这种历史的同龄人更快地经历心肺老化，从而增加CVD的风险。版权所有：©2023年麦迪逊等人。这是一篇开放获取文章，根据知识共享署名许可协议分发，允许在任何媒体上无限制使用、分发和再现，前提是原作者和来源得到了贷记。

Breast cancer survivors live longer due to more advanced cancer treatments; however, cardiovascular disease (CVD) is the leading non-cancer cause of death in breast cancer survivors. Previous studies have shown that depression is associated with an increased risk of CVD development. This study investigated whether depressive symptoms or mood disorder history, either independently or in combination with cardiotoxic treatments, predicted older cardiopulmonary age using a novel index-the Age Based on Exercise Stress Test (ABEST)-among breast cancer survivors.Breast cancer survivors (N = 80, ages 26-72, stage I-IIIA) were assessed an average of 53 days (SD = 26) post-surgery, but before adjuvant treatment, and again an average of 32 (SD = 6) months thereafter. At both visits, they reported depressive symptoms on the Center for Epidemiologic Studies Depression Scale (CES-D), completed the Structured Clinical Interview for DSM-V, and engaged in an exercise stress test to obtain ABEST scores.Controlling for treatment type, age, education, trunk fat, antidepressant use, and time between visits, longitudinal analyses showed that breast cancer survivors with a mood disorder history had worsening ABEST scores over time, compared to their peers without this history (p = .046). Change in physical activity between Visits 1 and 2 did not mediate this relationship (95% CI: -0.16-0.51). Ancillary analyses provided some additional support for the primary finding, such that those with a mood disorder history trended toward greater decreases in Vo2max, although results were marginally non-significant (p = .095). There were no cross-sectional relationships between depressive symptoms or mood disorder history and ABEST scores (ps>.20). Treatment type did not modulate observed relationships (ps>.22).Breast cancer survivors with a mood disorder history may experience faster cardiopulmonary aging compared to their peers without such a history, raising risk for CVD.Copyright: © 2023 Madison et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.