JC多瘤病毒（JCV）是编码T抗原蛋白的人类多瘤病毒，与癌症发生有关。JCV在上消化道和下消化道普遍存在。一些研究报告了JCV与结直肠癌（CRC）发展风险的关联，但这些结果仍存在争议。由于JCV DNA可能存在于健康组织以及转化后的组织中，JCV T抗原表达可能是JCV与癌症发展相关性的更有用的测量指标。本研究的目的是对病例-对照研究进行荟萃分析，以研究JCV T抗原蛋白表达与CRC风险之间是否存在显著关联。进行系统性回顾以确定报告CRC中JCV DNA流行率和JCV T抗原表达的研究。关联强度由几率比（ORs）估计。有5项（共66项）满足分析纳入标准，时间跨度为1999年至2022年。对CRC病例与对照组的随机效应荟萃分析表明，JCV DNA阳性样本中JCV T抗原表达与正常组织相比，CRC发展的风险增加了11倍（OR为10.95; 95％CI：2.48-48.24; P = 0.0016）。这篇JCV感染随后JCV T抗原蛋白表达与CRC风险的荟萃分析结果支持了JCV感染显著增加JCV T抗原蛋白表达组织的结直肠癌风险的观点。需要进一步研究JCV T抗原表达与CRC发展的关系。版权所有：©2023 Kimla等人。本文是按照创作共用许可证发布的开放获取文章，允许在任何媒介中无限制使用，分发和再现，只要保留原始作者和来源。

JC Polyomavirus (JCV) is a human polyomavirus encoding T-antigen protein, which is implicated in carcinogenesis. JCV is prevalent in the upper and lower gastrointestinal track. Several studies have reported JCV associations with the risk of developing colorectal cancer (CRC), however, these findings remain controversial. Since JCV DNA may be present in healthy tissues as well as transformed tissues, JCV T-antigen expression could be a more useful measure of JCV's association with cancer development. The aim of this study is to conduct a meta-analysis of case-control studies to investigate if there is a significant association between JCV T-antigen protein expression and risk of CRC. A systematic review was performed to identify studies reporting JCV DNA prevalence in CRC and JCV T-antigen expression. The strength of the association was estimated by odds ratios (ORs). Five (of 66) studies satisfied analysis inclusion criteria, and spanned years 1999 to 2022. Random effects meta-analysis of CRC cases versus controls showed an 11-fold increased risk of CRC development in JCV DNA positive samples with JCV T-antigen expression versus normal tissues (OR 10.95; 95% CI: 2.48-48.24; P = 0.0016). The results of this meta-analysis of JCV infection followed by JCV T-antigen protein expression for the risk of CRC support the argument that JCV infection significantly increases the risk of colorectal cancer in tissues where the JCV T-antigen protein is expressed. Further research with JCV T-antigen expression in relation to CRC development is needed.Copyright: © 2023 Kimla et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.