脑半球婴儿型胶质瘤是儿童高级别胶质瘤的新亚型，发生在大脑半球。尽管存活率有所提高，婴儿型脑半球胶质瘤的治疗仍面临挑战。在此，我们报告了一例有肺转移的QKI-ALK融合型婴儿型脑半球胶质瘤在接受了洛拉替尼治疗后实现了完全临床反应的情况。这个典型病例展示了在ALK融合瘤中使用适当的分子靶向治疗的重要性，洛拉替尼可以作为传统化疗和放疗的有效补充，用于治疗ALK融合型原发性胶质瘤及其转移。 © 2023年作者。Annals of Clinical and Translational Neurology由Wiley Periodicals LLC代表美国神经病学协会出版。

Infant-type hemispheric glioma, a new subtype of pediatric high-grade glioma, arises in the cerebral hemispheres. Despite better survival outcomes, the treatment of infant-type hemispheric glioma is still facing challenges. Here, we reported a case of QKI-ALK fusion, infant-type hemispheric glioma with lung metastasis who achieved a complete clinical response after lorlatinib treatment. This typical case demonstrated the importance of appropriate molecularly targeted treatments in ALK-fused tumors, and lorlatinib may serve as an effective complement to conventional chemotherapy and radiotherapy in primary glioma harboring ALK fusions and its metastasis.© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.