纵向研究。医学磁共振成像中的扫描技术——分子內不稳定运动（IVIM），有效用于定量评估脊椎骨恶性肿瘤。我们假设，脊椎体的IVIM参数与骨质疏松性脊椎压缩骨折（OVF）的预后相关。我们旨在探讨IVIM参数在OVF后椎体塌陷和不愈合方面的关系，并计算这些参数的破裂和不愈合的阈值值。共有150名患有急性OVF的患者（150名女性；平均年龄：79.1±7.4岁）并通过支撑保守治疗。在受伤时进行了MRI检查。记录了IVIM参数，如表观扩散系数（ADC）、分子扩散系数（D）和灌注相关扩散（D *）。将患者分为三组：低塌陷组（高度损失≤50%）、高塌陷组（高度损失>50%）和不愈合组。我们比较了低塌陷组、高塌陷组和不愈合组的ADC、D和D*，并进行了受试者工作特征（ROC）曲线分析，以确定高塌陷和不愈合组的界限值。低塌陷组、高塌陷组和不愈合组的ADC和D没有显著差异。然而，D*在三组之间有显著差异。ROC分析显示，高塌陷组和不愈合组的截止值分别为19.0×10-3mm2/s和12.3×10-3mm2/s。D*是预测OVF高位塌陷和不愈合组的重要指标。这表明在评估OVF时应考虑D*。

Longitudinal study.Intravoxel incoherent motion (IVIM), a magnetic resonance imaging (MRI) scanning technique that applies diffusion-weighted imaging (DWI), is effective for the quantitative assessment of malignant tumors of the vertebral bone. We hypothesized that IVIM parameters of vertebral bodies are associated with the prognosis of osteoporotic vertebral fracture (OVF). We aimed to explore the relationships between IVIM parameters for vertebral collapse and non-union after OVF and calculate the cut-off values of these parameters for vertebral collapse and non-union.A total of 150 patients with acute OVF (150 women; mean age: 79.1 ± 7.4 years) were included and treated conservatively with bracing. MRI was performed at the time of injury. IVIM parameters, such as apparent diffusion coefficient (ADC), molecular diffusion coefficient (D), and perfusion-related diffusion (D*) were recorded. The patients were classified into 3 groups: low-collapse (height loss of ≤50%), high-collapse (height loss of >50%), and non-union. We compared ADC, D, and D* among the low-collapse, high-collapse, and non-union groups and performed a receiver operating characteristic (ROC) curve analysis to determine the boundary values of the high-collapse and non-union groups.The low-collapse, high-collapse, and non-union groups had no significant differences in ADC and D. However, D* differed significantly among the 3 groups. ROC analysis revealed cut-off values of 19.0 × 10-3 mm2/s and 12.3 × 10-3 mm2/s for the high-collapse and non-union groups, respectively.D* is a significant prognostic indicator for high-collapse and non-union groups with OVF. This suggests that D* should be considered when assessing OVF.