乳腺癌（BC）是全球威胁女性生命最常见的癌症类型。临床上，针对目前治疗策略的多样性抗药性高的情况，需要开发新的有效方法来高效治疗BC。免疫治疗之一的嵌合抗原受体T（CAR-T）细胞疗法已经显示出强大的能力，可以特异性地杀灭和消除肿瘤。由于CAR-T疗法在治疗血液系统恶性肿瘤方面的成功，CAR-T细胞疗法的效果已经在包括乳腺癌在内的各种人类疾病中进行过测试。本综述总结和讨论了CAR-T疗法在乳腺癌中的应用状况，包括CAR-T疗法在研究和临床应用中的进展、挑战和对策。还强调了潜在抗原靶点、肿瘤微环境、免疫逃避在调节CAR-T疗法中的作用，以及将CAR-T疗法与其他治疗策略结合以进一步提高CAR-T疗法的治疗效果。因此，我们的综述提供了对CAR-T细胞疗法在乳腺癌中的全面了解，这将唤起未来对基于CAR-T的癌症治疗的深入研究的兴趣。 版权所有©2023，由Elsevier Masson SAS出版。保留所有权利。

Breast cancer (BC) is the most frequently occurring cancer type seriously threatening the lives of women worldwide. Clinically, the high frequency of diverse resistance to current therapeutic strategies advocates a demand to develop novel and effective approaches for the efficient treatment of BC. The chimeric antigen receptor T (CAR-T) cells therapy, one of the immunotherapies, has displayed powerful capacity to specifically kill and eliminate tumors. Due to the success of CAR-T therapy achieved in treating hematological malignancy, the effect of CAR-T cells therapy has been tested in various human diseases including breast cancer. This review summarized and discussed the landscape of the CAR-T therapy for breast cancer, including the advances, challenge and countermeasure of CAR-T therapy in research and clinical application. The roles of potential antigen targets, tumor microenvironment, immune escape in regulating CAR-T therapy, the combination of CAR-T therapy with other therapeutic strategies to further enhance therapeutic efficacy of CAR-T treatment were also highlighted. Therefore, our review provided a comprehensive understanding of CAR-T cell therapy in breast cancer which will awake huge interests for future in-depth investigation of CAR-T based therapy in cancer treatment.Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.