Discs large homolog 5（DLG5）是膜关联鸟苷酸酰化酶（MAGUKs）家族的重要成员，是一个信号转导复合物的支架分子，负责组装受体和适配器。这个支架蛋白稳定了许多器官和组织中的粘附和紧密结合复合物，参与了维持上皮极性。虽然DLG5在小鼠的正常发育中发挥作用，但它也被发现与几种疾病的发生和发展有关，特别是克罗恩病和各种恶性肿瘤。DLG5已被证明通过与H-Catenin、E-Cadherin、Vimentin、p53、P21、Cyclin D1、TGF-β1、AKT、Hippo和经典的G蛋白信号通路的直接或间接相互作用影响肿瘤的进展。DLG5和DLG5变异体在人类疾病中发挥双重作用。虽然在胰腺腺癌中表达过高，但在肺癌、肝癌、乳腺癌、前列腺癌和膀胱癌中其表达却降低。然而，两项关于恶性胶质母细胞瘤（GBM）的独立研究表明了DLG5的相反效应。我们的研究评估了DLG5和DLG5变异体在疾病过程中的作用，并总结了基于细胞实验、临床样本和动物模型的DLG5在疾病中的可用数据，同时强调了其在疾病治疗中的未来潜力。版权所有© 2023年作者。由Elsevier Masson SAS出版。保留所有权利。

Discs large homolog 5 (DLG5), a key member of the membrane-associated guanylate kinase (MAGUKs) family, is a scaffold molecule for signal transduction complexes and is responsible for assembling receptors and adapters. This scaffold protein stabilizes adhesion and tight bonding complexes in many organs and tissues, and is involved of maintaining epithelial polarity. Although DLG5 plays a role in normal development in mice, it has also been linked to the onset and development of several diseases, particularly Crohn's disease and various malignancies. DLG5 has been shown to impact the progression of cancer through direct or indirect interactions with H-catenin, E-cadherin, Vimentin, p53, P21, Cyclin D1, TGF-β1, AKT, Hippo, and classic G protein signaling pathways. DLG5 and DLG5 variants has been found to have a dual role in human diseases. Although it is overexpressed in pancreatic adenocarcinoma, its expression is reduced in lung, liver, breast, prostate, and bladder cancers. However, two independent studies on glioblastoma (GBM) have shown the opposite effects of DLG5. Our study evaluates the existing literature on the role of DLG5 and DLG5 variants in disease processes, and summarizes the available data on the role of DLG5 in disease based on cell experiments, clinical samples, and animal models, while highlighting its future potential in disease treatment.Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.