Organoid技术正在迅速发展，并具有在疾病建模和临床转化研究中的巨大潜力和希望。然而，它们也引发了许多关于当前和未来使用的复杂伦理问题。患者和公众的参与对建立公众信任和帮助确保负责任的行为和有价值的创新非常重要；然而，对于患者和公众对Organoid技术的看法的研究仍然很少。我们通过三场跨国家的协商研讨会对一组不同利益相关者进行了第一次Organoid技术的公共对话，以确定他们的态度和关注点。参与者普遍支持Organoid技术，但前提是要建立负责任的治理、伦理监管和完善的知情同意程序。然而，还存在着一系列可能的关切，主要涉及商业化、医疗保健准入和脑器官oid技术。参与者的见解和建议可以帮助研究人员以及伦理和政策机构支持负责任和伦理的Organoid方法。版权©2023年作者。由Elsevier公司出版。保留所有权利。

Organoid technologies are rapidly advancing and hold great potential and hope for disease modeling and clinical translational research. Still, they raise a number of complex, ethical questions regarding their current and future use. Patient and public involvement is important in building public trust and helping to secure responsible conduct and valued innovations; nevertheless, research into patient and public perspectives on organoid technologies remains scarce. We report on a first public dialogue on organoid technologies through three cross-country deliberative workshops with a diverse group of stakeholders to identify their perceptions and concerns. Participants generally support organoid technologies on the condition that responsible governance, ethical oversight, and sound informed consent procedures are in place. Yet, a broad set of potential concerns are identified, primarily concerning commercialization, healthcare access, and cerebral organoids. Participants' insights and recommendations can help inform researchers and ethics and policy bodies toward supporting responsible and ethical organoid approaches.Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.