在免疫检查点阻断治疗肺癌患者中，映射出了一种持续性T细胞衰竭计划。
A progressive T cell exhaustion program mapped across tissues in patients with lung cancer on immune checkpoint blockade.
发表日期：2023 Mar 10
作者：
Carolina Mangana, Barbara B Maier
来源：
CANCER CELL
摘要：
免疫检查点阻断已成为肺癌患者的标准治疗。然而，在患者中的作用方式仍未完全了解。在本期中，Pai等人提供了肺癌患者PD-1阻断治疗下瘤向T细胞的时空分辨率分化图。 版权所有©2023 Elsevier Inc.。
Immune checkpoint blockade has reached the standard of care for patients with lung cancer. However, its mode of action in patients is still incompletely understood. In this issue, Pai et al. present a temporally and spatially resolved differentiation map of tumor-directed T cells in patients with lung cancer on PD-1 blockade.Copyright © 2023 Elsevier Inc. All rights reserved.