建模衰老和癌症的挑战与机遇。
Challenges and opportunities for modeling aging and cancer.
发表日期：2023 Mar 22
作者：
Olga Anczuków, Susie Airhart, Jeffrey H Chuang, Lisa M Coussens, George A Kuchel, Ron Korstanje, Sheng Li, Anna Lisa Lucido, Sandra S McAllister, Katerina Politi, Kornelia Polyak, Timothy Ratliff, Gary Ren, Jennifer J Trowbridge, Duygu Ucar, Karolina Palucka
来源：
BIOMEDICINE & PHARMACOTHERAPY
摘要：
年龄是癌症的主要风险因素之一，任何成人的癌症研究都面临着组织和有机体的老化。然而，临床前研究使用年轻的小鼠进行，无法解决老化和相关共病对疾病生物学和治疗结果的影响。在这里，我们讨论当前小鼠癌症模型的局限性，并建议发展新模型的策略来解决知识和实验方法上的这些重大差距。版权所有©2023 Elsevier Inc.。
Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated comorbidities on disease biology and treatment outcomes. Here, we discuss the limitations of current mouse cancer models and suggest strategies for developing novel models to address these major gaps in knowledge and experimental approaches.Copyright © 2023 Elsevier Inc. All rights reserved.