谷胱甘肽过氧化物酶4（GPx4）兼御结构蛋白和抗氧化酶，能有效抑制脂质氧化。在过去的几年里，它被认为是铁死亡的关键调节因子，参与脂质和氨基酸代谢，影响细胞老化、致癌和细胞死亡。越来越多的证据表明，针对GPX4诱导的铁死亡是一种有前途的疾病治疗策略，特别是癌症治疗。鉴于此，我们总结了GPX4的功能以及GPX4和铁死亡之间的调节机制，讨论了它在疾病病理学中的作用，并关注了疾病治疗潜力的最新进展。 版权所有©2023 Elsevier B.V.出版。

Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of ferroptosis, which takes role in the lipid and amine acid metabolism and influences the cell aging, oncogenesis, and cell death. More and more evidences show that targeting GPX4-induced ferroptosis is a promising strategy for disease therapy, especially cancer treatment. In view of these, we generalize the function of GPX4 and regulatory mechanism between GPX4 and ferroptosis, discuss its roles in the disease pathology, and focus on the recent advances of disease therapeutic potential.Copyright © 2023. Published by Elsevier B.V.