使用羟丙基甲基纤维素（HPMC）和羧甲基纤维素钠（CMC）制备了姜黄素固体分散体（Cur SDs）在不同剂量下。傅里叶变换红外光谱和拉曼光谱的结果显示姜黄素的特征峰发生了移位，而CMC的添加增强了这种现象。添加CMC减小了接触角，增加了表面自由能，并改善了Cur SDs的溶解性。这些变化与CMC的数量呈正相关。扫描电镜观察到，Cur SDs的表面形态由针状变为片状。使用CMC和HPMC制备的Cur SDs保持良好的生物活性。HT-29人类结肠癌细胞分析表明，CMC的添加显著提高了Cur SDs的抗增殖效果，从而提高了姜黄素的生物利用度。使用CMC和HPMC制备的固体分散体将是一种有前途的水溶胶体载体，可提高姜黄素的口服生物利用度和疗效。版权所有©2023 Elsevier B.V. 发布。

Curcumin solid dispersions (Cur SDs) were prepared using hydroxypropyl methyl cellulose (HPMC) and sodium carboxymethyl cellulose (CMC) at different dosages. The results of Fourier transform infrared spectroscopy and Raman spectroscopy showed that the characteristic peak of curcumin shifted, and the addition of CMC enhanced this phenomenon. The addition of CMC reduced the contact angle, increased the surface free energy, and improved the solubility of Cur SDs. These changes were positively correlated with the amount of CMC. The surface morphology of Cur SDs changed from needle-like to sheet-like as observed by scanning electron microscopy. Cur SDs prepared by CMC and HPMC retained good biological activity. HT-29 human colon cancer cell analysis showed that the addition of CMC significantly improved the anti-proliferation effect of Cur SDs, thus enhancing the bioavailability of curcumin. Solid dispersions made with CMC and HPMC will be a promising hydrocolloid carrier to improve oral bioavailability and efficacy of curcumin.Copyright © 2023. Published by Elsevier B.V.