Oncoytic病毒（OV）是一个有吸引力的前景，因为它们具有直接溶解细胞和增强抗肿瘤免疫反应的双重攻击机制。在肿瘤治疗临床试验中使用各种肿瘤溶解病毒载体，而它们的主要问题之一是在全身输送过程中被网状内皮系统清除。由于药物传递的非特异性及其在血液循环中的消除，纳米颗粒（NPs）在临床试验中受到了广泛关注。在这方面，为了增加纳米颗粒的药物传递效率，可以对其表面进行各种化学修饰。为了提高这两种治疗选择的性能，可以使用封装有纳米颗粒的OV的复杂策略，这在治疗各种癌症方面已取得成功的临床结果。在这里我们将回顾每种治疗方法及其功能机制。版权所有©2023 Elsevier B.V.发表。

Oncolytic viruses (OV) are an attractive prospect due to their dual attack mechanism of direct cell lysis and potentiation of an antitumor immune response. Various oncolytic viral vectors are used in oncotherapy clinical trials, and one of their main problems is elimination by the reticuloendothelial system during systemic delivery. Nanoparticles (NPs) have received much attention in clinical trials due to their unique appearance characteristics, but they have created challenges due to the non-specificity of drug delivery to the target tissue and its elimination in blood circulation. In this regard, to increase the efficiency of nanoparticles in drug delivery, various chemical modifications can be applied to the surface of nanoparticles. To improve the performance of these two treatment options, the complex strategy of OVs encapsulated with nanoparticles can be used, which has brought successful clinical results in the treatment of various cancers. Here we will review each of the treatment methods and their functional mechanism.Copyright © 2023. Published by Elsevier B.V.