本系统性综述和Meta分析旨在研究在癌症患者接受主动治疗期间，家庭锻炼对身体健康（心肺健康、肌肉强度和身体成分）的影响。本研究进行了系统性综述和Meta分析及证据的定级推荐评估（GRADE）。通过在四个电子数据库（PubMed、Web of Science、Scopus和PEDro）进行全面的现有文献搜索，寻找询身体健康结果影响癌症患者的家庭锻炼的随机对照试验。但排除了多成分干预（即锻炼加饮食/行为疗法）。使用修订后的Cochrane随机试验风险偏倚工具对每个研究的方法学质量进行评估。在适当的情况下进行Meta分析程序，并计算标准化平均差异（SMD）。 本研究包括28个随机对照试验（n = 2424癌症患者）。大多数干预措施是在乳腺癌患者（n = 13）在辅助治疗期间（n = 17）进行的；18项研究在其家庭锻炼方案中包括散步部分。家庭锻炼可以有效提高6分钟步行测试评估距离（K = 6; SMD = 0.321，p = 0.010）。但是，在仅限步行（k = 1）和非仅限步行干预（k = 5; SMD = 0.258; p = 0.072）的敏感性分析中进行结果，结果不再显著。对于肌肉强度和身体成分的结果没有发现效果（p> 0.05）。 定期的家庭锻炼计划是改善癌症患者进行主动治疗时6分钟步行测试的有效策略。相反，没有发现肌肉强度和身体成分的影响。版权所有©2023作者。由Elsevier Ltd.发表，保留所有权利。

This systematic review and meta-analysis aimed to investigate the effects of home-based exercise on physical fitness (cardiorespiratory fitness, muscle strength, and body composition) in cancer patients undergoing active treatment.Systematic review with meta-analysis and Grading Recommendations Assessment, Development, and Evaluation of the evidence.A comprehensive search of existing literature was carried out in four electronic databases: PubMed, Web of Science, Scopus, and PEDro. All databases were searched for randomized controlled trials assessing the effects of home-based exercise on physical fitness outcomes in cancer patients during active treatment. Multicomponent interventions (i.e., exercise plus diet/behavioral therapy) were excluded. The methodological quality of each study was assessed using the Revised Cochrane risk-of-bias tool for randomized trials. Meta-analytical procedures were performed when appropriate and standardized mean differences (SMD) were calculated.Twenty-eight randomized controlled trials (n = 2424 cancer patients) were included. Most of the interventions were conducted in breast cancer patients (n = 13) during the adjuvant treatment period (n = 17); 18 studies included a walking component in their home-based protocol. Home-based exercise was effective at improving the distance of the 6-minute walk test (k = 6; SMD = 0.321, p = 0.010). However, the results were no longer significant when performing sensitivity analysis based on exclusively walking (k = 1) and non-exclusively walking interventions (k = 5; SMD = 0.258; p = 0.072). No effects were found for muscle strength and body composition outcomes (p > 0.05).Regular home-based exercise programs are an effective strategy to improve 6-minutes walk test in cancer patients undergoing active treatment. Conversely, no alterations were found in muscle strength and body composition.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.