我们利用恶性胸膜间皮瘤（MPM）接受胸膜外肺切除术（EPP）的患者数据，评估了五个复杂的炎症和营养参数的预测价值，即中性粒细胞/淋巴细胞比（NLR），预后营养指数（PNI），C-反应蛋白/ NLR比（C / NLR），血小板/淋巴细胞比（PLR）和淋巴细胞/单核细胞比（LMR）。此外，还评估了这五个参数与程序性细胞死亡蛋白1配体1（PD-L1）在肿瘤微环境中的表达之间的相关性。该研究包括连续进行EPP的MPM患者。符合条件的患者（n = 61）的组织学亚型与所有五个参数相关。此外，免疫细胞中的PD-L1表达分数与NLR和PLR相关，而肿瘤细胞和免疫细胞的PD-L1表达分数分别与PNI和LMR呈负相关。单变量分析阐明NLR，PNI和C / NLR是5年总体生存率（OS）的预测因子，多变量分析揭示NLR是5年OS的独立预测因子，这表明NLR是接受EPP的MPM患者的一种术前预后因子。据我们所知，这是第一项同时评估NLR，PNI，C / NLR，PLR和LMR在接受EPP的MPM患者中的预后潜力的研究。©2023。作者。

We assessed the prognostic value of five complex inflammatory and nutritional parameters, namely neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), C-reactive protein-to-NLR ratio (C/NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) using data from patients with malignant pleural mesothelioma (MPM) undergoing extrapleural pneumonectomy (EPP). Moreover, the correlation between these five parameters and programmed cell death protein 1 ligand-1 (PD-L1) expression in the tumor microenvironment was evaluated. This study included consecutive MPM patients who underwent EPP. The histological subtype of the eligible patients (n = 61) correlated with all five parameters. Moreover, the PD-L1 expression scores for immune cells correlated with NLR and PLR, and the PD-L1 expression scores for both tumor cells and immune cells were inversely correlated with both PNI and LMR. Univariate analysis elucidated that NLR, PNI, and C/NLR were predictors of 5-year overall survival (OS), and multivariate analysis revealed that NLR was an independent predictor of 5-year OS, suggesting that NLR is a preoperative, prognostic factor for patients with MPM who are scheduled for EPP. To the best of our knowledge, this is the first study to evaluate the prognostic potentials of NLR, PNI, C/NLR, PLR, and LMR simultaneously in patients with MPM who underwent EPP.© 2023. The Author(s).