Lathyrol是Euphorbia lathyrism所分离的许多lathyrane二萜具有强效抗炎活性的核心支架结构。它被选择作为设计和合成一系列蛋白酶降解靶向嵌合体的框架。共获得15个衍生物。化合物13在RAW264.7细胞中抑制LPS诱导的NO产生有抑制作用（IC50 = 5.30 ± 1.23 μM），且细胞毒性低。此外，化合物13会浓度依赖性和时间依赖性地明显降解lathyrane二萜的靶标v-maf musculoaponeurotic fibrosarcoma oncogene homologue F (MAFF)蛋白。13的作用机制与激活Keap1/Nrf2通路有关。它还抑制了NF-κB的表达，阻碍了NF-κB的核转移，并激活了LPS诱导的RAW264.7细胞的自噬。基于所获得的结果，化合物13可能是一种有前途的抗炎药物。

Lathyrol is a core scaffold structure of many lathyrane diterpenoids with potent anti-inflammatory activity isolated from Euphorbia lathyrism. It was chosen as a framework to design and synthesize a series of proteolysis targeting chimeras. A total of 15 derivatives were obtained. Compound 13 exhibited inhibitory activity on LPS-induced NO production in RAW264.7 cells (IC50 = 5.30 ± 1.23 μM) with low cytotoxicity. Furthermore, compound 13 significantly degraded v-maf musculoaponeurotic fibrosarcoma oncogene homologue F (MAFF) protein, a target of lathyrane diterpenoid, concentration- and time-dependently. The mechanism of action of 13 is related to activating the Keap1/Nrf2 pathway. It also inhibited the expression of NF-κB, blocked the nuclear translocation of NF-κB, and activated autophagy in LPS-induced RAW264.7 cells. Based on the results obtained, compound 13 might be a promising anti-inflammatory agent.