前列腺组织活检是一种测试，旨在取出一小部分前列腺组织以在显微镜下检查。当血液测试显示前列腺特异性抗原(PSA)水平过高或数字直肠检查发现异常前列腺或肿块时可能进行活检。经直肠超声引导活检是检测前列腺癌的常见操作。它与尿道败血症等严重并发症有关。尽管TRUS术后尿道败血症的发生率低，但当其发生时通常是严重的，并导致住院治疗。在TRUS活检过程中事先、期间和之后使用抗生素预防因TRUS活检而导致的感染。环丙沙星已经被长期用作抗生素。抗生素预防可能可以预防这些并发症。本横断面的观察性描述性研究从2010年1月至2011年12月在孟加拉国达卡医学院医院对有目的地选择的70名患者进行了研究，旨在确定TRUS引导前列腺活检后的尿道败血症和细菌尿症。在DMCH泌尿科门诊接受LUTS和其他非特异性症状治疗的患者通过病史、体格检查，包括数字直肠检查(DRE)和必要的调查，如血清PSA来确定潜在候选人。具有异常DRE结果和升高的PSA水平的患者被纳入这项研究，并排除任何疼痛的肛门和直肠疾病、出血倾向、抗凝治疗和任何已知对利多卡因过敏、以前进行了前列腺活检和拒绝签署知情同意书的患者。数据根据结构化案例记录表收集感兴趣的变量。数据使用社交科学统计软件(SPSS) 17.0版进行处理和分析。根据尿液和血液培养报告，测量尿道败血症和细菌尿症的频率。还看到了敏感性模式。根据这项研究，细菌尿症和尿道败血症的频率分别为17.1%和5.7%。最常见的尿路病原体是大肠杆菌，尿和血培养都是如此。在细菌培养阳性患者中，发现的细菌(100%)对环丙沙星和阿莫西林都具有抵抗力。大多数病原体对万古霉素、庆大霉素和头孢哌酮是敏感的。在25.0%的培养阳性患者中检测到一种潜在危险的环丙沙星耐药菌(ESBL产生的大肠杆菌)阳性。

A prostate gland biopsy is a test to remove small sample of prostate tissue to be examined under a microscope. A biopsy may be done when a blood test shows a high level of prostate-specific antigen (PSA) or after a digital rectal examination finds an abnormal prostate or a lump. Transrectal ultrasound (TRUS) guided biopsy is a commonly performed procedure for the detection of prostate cancer. It is associated with serious complication like urosepsis. Although the incidence of post-TRUS urosepsis is low, when it occurs it is typically serious and leads to hospitalization. Antibiotics are used prior, during and after the procedure to prevent infections as a result of TRUS biopsy. Ciprofloxacin is being used as antibiotic of choice for a long time. Antibiotic prophylaxis may prevent such complications. This cross-sectional descriptive type of observational study was taken place in Dhaka Medical College Hospital, Dhaka, Bangladesh from January 2010 to December 2011 among purposively selected 70 patients with an aim to determine the urosepsis and bacteriuria after TRUS guided prostate biopsy. Patients attending the Urology OPD in DMCH having of LUTS and other non-specific symptoms were evaluated by history, physical examination including digital rectal examination (DRE) and necessary investigations like serum PSA to identify the potential candidates. Patients with abnormal DRE findings and increased PSA level were included in this study and those who had any painful anal and rectal condition, bleeding diathesis, anticoagulant therapy and any known allergy to lidocaine, previously undergone prostrate biopsy and those who refused to give the informed consent were excluded from this study. Data were collected on variables of interest using a structured case record form. Data were processed and analyzed using Statistical package for social science (SPSS), version 17.0. Frequency of bacteriuria and urosepsis was measured according to urine and blood culture report. Sensitivity pattern was also seen. According to this study, the frequency of bacteriuria and urosepsis was 17.1% and 5.7% respectively. Most common uropathogen was E coli both in urine and blood culture. Organisms (100.0%) were found resistant to ciprofloxacin and amoxicillin. Most of the pathogens were sensitive to tobramycin, gentamycin and cefipime. A potentially dangerous ciprofloxacin resistant organism (ESBL producing E. coli) was found positive in 25.0% of culture positive patients.