结直肠癌是肠道最常见的癌症。超过 95.0％ 的癌症是腺癌。黏液腺癌占所有结直肠癌的约 10.0％。黏液的表达本身可能在肿瘤细胞逃避全身治疗和肿瘤进展、浸润、生存和保护宿主免疫反应的过程中起到作用。黏液湖也可能成为传递靶向治疗到肿瘤细胞的生理屏障。本研究的目的是评估和比较结直肠腺癌中黏液和非黏液腺癌形态学和组织学预后因素。在这个描述性横断面观察性研究中，从 2017 年和 2018 年共评估了 98 个结直肠腺癌样本的黏液存在或不存在。该研究是在已内嵌瘤组织的石蜡中进行的，其切片使用苏木精-伊红染色技术着色。黏液通过周期酸染色和葡萄糖酸酶周期酸染色进行评估。总共，98 例结直肠腺癌患者中有 27 例（27.6％）为黏液组织学亚型。本研究发现的统计显著性结果如下：黏液亚型倾向于伴有中度贫血、低纤维素摄入史和更大的肿瘤大小、近端结肠受累、浸润形态学和高 II 期比非黏液组织学亚型。在结直肠癌患者中，黏液组织学亚型与一些不良病理特征有关。

Colorectal carcinoma is the most common cancer of the gastrointestinal tract. More than 95.0% of the cancer is adenocarcinoma. Mucinous adenocarcinomas account for about 10.0% of all colorectal cancers. The expression of mucin themselves may play a role in the ability of tumors cells to escape the effect of systemic therapy and the process of tumor progression, invasion, survival and protection against the host immune response. The mucin lakes may also be a physiological barrier for the delivery of targeted therapy to the tumors cells. The aim of this study was to evaluate and compare the morphologic and histologic prognostic factors of mucinous and non-mucinous adenocarcinoma of the colon and rectum. In this descriptive cross-sectional type of observational study a total of 98 samples with colorectal adenocarcinoma were evaluated on the basis of presence or absence of the mucin from 2017 and 2018. The study was conducted in paraffin-embedded tumor tissue whose slides were stained using the hematoxylin-eosin technique. Mucin was evaluated by Periodic acid schiff and Diastase periodic acid schiff stain. Totally, 27 of 98 patients with colorectal adenocarcinoma (27.6%) had mucinous histologic subtype. Statistical significant results found in this research are as follows: Mucinous subtype tended to have present with moderate anaemia, history of low vegetable diet and larger tumor size, proximal colon involvement, infiltrative morphology and higher stage II compared to non-mucinous histologic subtype. Mucinous histologic subtype was associated with some adverse pathologic features in patients with colorectal cancer.