Porocarcinoma（PC）是一种分化向汗管和汗腺的皮肤恶性肿瘤。由于缺乏组织学诊断标志物，临床和病理诊断变得复杂。目前有限的数据表明发病率在增加，但这一点仍需在全国流行病学研究中加以确认。利用全国癌症登记数据从2013年1月1日至2018年12月31日报告英格兰PC的发病率、治疗和生存情况。通过形态和行为编码从国家疾病登记服务中确定英格兰2013-2018年的PC诊断结果。这些结果来自于例行收集的病理报告和癌症结果及服务数据集。计算2013年欧洲年龄标准化发病率（EASR）、Kaplan Meier全因生存率和对数秩检验。共诊断出738个肿瘤，其中男性396例，女性342例。诊断的中位年龄为82岁（四分位距74-88岁）。最常受影响的部位为下肢（35.4％），其次是面部（16％）。大多数患者接受了手术切除（72.9％）。Kaplan Meier全因生存率在5年时为45.4％，低于先前的研究结果。整个人群的EASR为0.25 [95％置信区间（CI）0.23-0.27]每10万人年。东英格兰的PC发病率[EASR为0.54（95％ CI 0.47-0.63）每10万人年]是西南地区发病率[EASR为0.14（95％ CI 0.10- 0.19）每10万人年]的三倍，而该地区的发病率最低。该研究表明，英格兰各地区的PC EASR存在很大差异。这可能反映了PC在不同地区的诊断和登记差异。这些数据支持对porocarcinoma管理的全国评估，这将为未来的研究和指南开发提供帮助。© The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists.

Porocarcinoma (PC) is a cutaneous malignancy that differentiates towards the sweat ducts and glands. Lack of histological diagnostic markers makes clinical and pathological diagnosis complex. Limited data available suggests incidence is increasing, however this remains to be established in national epidemiological studies.To report the incidence, treatment and survival of PC in England from 1/01/2013 to 31/12/2018 using national cancer registry data.PC diagnoses in England during 2013-18 were identified from the National Disease Registration Service using morphology and behaviour codes. These were registered from routinely collected pathology reports and cancer outcomes and services datasets. 2013 European age standardised incidence rates (EASR), Kaplan Meier all-cause survival and log rank test were calculated.738 tumours, 396 in males and 342 in females, were diagnosed. The median age at diagnosis was 82 years old (interquartile range 74-88). The most frequently affected site were lower limbs (35.4%), followed by the face (16%). The majority of the cohort received surgical excision (72.9%). The Kaplan Meier all cause survival was 45.4% at 5 years, which was lower than in previous studies.The EASR for the whole population was 0.25 [95% confidence interval (CI) 0.23-0.27] per 100,000 person-years (PY)]. PC incidence rates in the East of England [EASR of 0.54 (95% CI 0.47-0.63) per 100,000 PY] were three times higher than the South West [EASR of 0.14 (95% CI 0.10-0.19) per 100,000 PY] where the regional rates were the lowest.This study showed that there is large variation in the EASR of PC across England. This may reflect differences in how PC is diagnosed and registered in different regions in England. These data support national assessment of the management of porocarcinoma, which will inform future studies and guideline development.© The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists.