肟肽受体2 (FPR2) 及其小鼠同源基因 Fpr2 是 G 蛋白偶联受体 (GPCR) 家族的成员。FPR2 是 FPR 家族中唯一与来自不同来源的配体相互作用的成员。FPR2 在髓系细胞、上皮细胞、内皮细胞、神经元和肝细胞中表达。在过去的几年中，FPR2 的一些不寻常特性引起了强烈关注，因为 FPR2 似乎具有双重功能，可以通过激活或抑制细胞内信号通路来控制开发和稳态信号级联反应，这取决于配体的性质、浓度以及细胞类型和微环境的时空设置。因此，FPR2 控制着广泛的发育和稳态信号级联反应，除了其 "经典" 的介导造血和非造血细胞包括恶性肿瘤细胞迁移的能力。在本综述中，我们总结了 FPR2 研究中的最新进展，特别是它在疾病中的作用，从而帮助确立 FPR2 作为潜在的治疗干预靶点。版权所有 © 2023 Elsevier B.V.。

Formyl peptide receptor 2 (FPR2) and its mouse counterpart Fpr2 are the members of the G protein-coupled receptor (GPCR) family. FPR2 is the only member of the FPRs that interacts with ligands from different sources. FPR2 is expressed in myeloid cells as well as epithelial cells, endothelial cells, neurons, and hepatocytes. During the past years, some unusual properties of FPR2 have attracted intense attention because FPR2 appears to possess dual functions by activating or inhibiting intracellular signal pathways based on the nature, concentration of the ligands, and the temporal and spatial settings of the microenvironment in vivo, the cell types it interacts with. Therefore, FPR2 controls an abundant array of developmental and homeostatic signaling cascades, in addition to its "classical" capacity to mediate the migration of hematopoietic and non-hematopoietic cells including malignant cells. In this review, we summarize recent development in FPR2 research, particularly in its role in diseases, therefore helping to establish FPR2 as a potential target for therapeutic intervention.Copyright © 2023 Elsevier B.V. All rights reserved.