Lynch综合症患者的内脏恶性肿瘤与非Lynch综合症患者相比行为较温和。Mu​​ir-Torre综合症（MTS）中皮脂腺癌（SC）的行为未经完全研究。研究有和无MTS的SC患者的特征和生存率。回顾队列研究涉及2000-2019年在监测、流行病学和终点事件17数据库中SC患者。根据Mayo MTS风险评分阈值为2将患者分为MTS或非MTS病例。我们确定了105例（2.8％）MTS病例和3677例（97.2％）非MTS病例。在单因素分析中，MTS患者更年轻，在头颈外的肿瘤比例更高，并且具有更少的高级别肿瘤。在Kaplan-Meier分析中，MTS患者趋向于具有更好的SC特定生存率。在其他协变量调整的多元Cox比例风险分析中，MTS状态是整体生存率较差的独立预测因素。但是，MTS状态与SC特定生存率之间没有关联。考虑到SC中较高的疾病特异性生存率，我们的研究可能没有足够的动力检测Kaplan-Meier分析上的差异。我们的研究表明，MTS患者的SC行为并不比非MTS患者更具攻击性。版权所有©2023年Elsevier Inc. 发布。

Visceral malignancies in patients with Lynch syndrome behave less aggressively than in those without Lynch syndrome. The behavior of sebaceous carcinoma (SC) in Muir-Torre syndrome (MTS), a variant of Lynch syndrome, is incompletely investigated.Investigate features and survival of SC patients with and without MTS.Retrospective cohort study in the Surveillance, Epidemiology, and End Results 17 database from 2000-2019 of patients with SC. Patients were classified as MTS or non-MTS cases based on a threshold score of 2 on the Mayo MTS Risk Score.We identified 105 (2.8%) MTS cases and 3677 (97.2%) non-MTS cases. On univariate analysis, MTS patients were younger, had a higher proportion of tumors outside the head/neck, and had fewer high-grade tumors. On Kaplan-Meier analysis, MTS patients trended toward having better SC-specific survival. On multivariate Cox proportional hazards analysis adjusting for other covariates, MTS status was an independent predictor of worse overall survival. However, there was no association between MTS status and SC-specific survival.Given relatively high disease-specific survival in SC, our study may have been underpowered to detect a difference on Kaplan-Meier analysis.Our study suggests SC does not behave more aggressively in patients with MTS.Copyright © 2023. Published by Elsevier Inc.