研究超声和血清标志物检测在髓样甲状腺癌（MTC）侧向淋巴结转移中的价值。收集2010年6月至2020年8月在北京协和医院普通外科诊断为MTC并入院的105例患者的数据并进行回顾性分析。超声检查单独具有89.36％的敏感性和70.69％的特异性。对于术后测定癌胚抗原和降钙素的监测，分别显示出7.115 ng/mL和13.185 pg/mL的阈值，能够区分颈部淋巴结转移的存在。将超声和术后血清中的癌胚抗原和降钙素水平作为序列测试的结合，特异性提高至91.38％和87.93％，敏感性为95.45％。多元 logistic 分析确定了MTC中侧向淋巴结转移的以下风险因素：超声检测到可疑淋巴结和术后降钙素>13.185 pg/mL。与单一测试相比，超声和血清学测试的组合能够实现更高的敏感性和特异性，以识别潜在的颈侧淋巴结转移的MTC病例。© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

To investigate the value of ultrasound and serum marker tests in detecting lateral lymph node metastasis in medullary thyroid cancer (MTC).Data of 105 patients diagnosed with MTC and admitted to the Department of General Surgery in Peking Union Medical College Hospital from June 2010 to August 2020 were collected and retrospectively analyzed.Ultrasound examination alone had a sensitivity of 89.36% and a specificity of 70.69%. For surveillance of postoperative carcinoembryonic antigen and calcitonin, cut-off values of 7.115 ng/mL and 13.185 pg/mL, respectively, were shown to discriminate the presence of cervical lymph node metastasis. Combining ultrasound and postoperative serum levels of both carcinoembryonic antigen and calcitonin as serial tests increased the specificity to 91.38% and 87.93%, with a sensitivity of 95.45%. Multivariate logistic analysis identified the following risk factors for lateral lymph node metastasis in MTC: suspicious lymph nodes detected by ultrasound and postoperative calcitonin above 13.185 pg/mL.The combination of ultrasound and serological tests achieved higher sensitivity and specificity to identify MTC cases with potential occult lateral cervical lymph node metastasis compared with single tests.© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.