肝细胞癌（HCC）在亚洲人和太平洋岛民（API）中高度普遍，但该异质性群体通常被合并为一个单一类别，尽管亚群之间在文化、社会经济地位、教育和医疗护理方面存在巨大差异。各API亚群之间HCC结果仍存在显著的知识差距。访问了监测、流行病学和终末结果（SEER）数据库，并使用部位/ICD代码识别2010-2019年期间API族裔的HCC患者。收集数据：人口统计学、社会经济地位、肿瘤特征、治疗和生存。在二次分析中，在不同的亚洲族裔之间进行亚组分析。共鉴定/细分了8,249名患者，分为亚洲族裔亚组和其他太平洋岛民（NHOPI）亚组。亚洲人的中位年龄为65岁，NHOPI为62岁（p < 0.01），在收入方面存在显著差异（p < 0.01）。相对于亚洲人的比例较高，NHOPI居住在农村地区（8.1% vs 1.1%，p < 0.01）。两组之间的肿瘤大小、分期、术前甲胎蛋白水平或手术治疗没有统计学上显着差异。然而，亚洲人的总体中位生存期要高于NHOPI（20个月对12个月，p < 0.01）。在不同亚洲族裔之间的二次分析中，发现肿瘤大小和分期、手术切除、移植率和中位生存期存在显着差异。虽然API具有类似的肿瘤特征和治疗方式，但亚洲人的生存率比NHOPI高得多。社会经济差异和医疗护理的可及性可能导致这些差异。本研究还发现API族裔之间存在显着的生存差距。© 2023。本文作者，独家授权给Springer Science + Business Media, LLC，Springer Nature的一部分。

Hepatocellular carcinoma (HCC) is highly prevalent in Asians and Pacific Islanders (API) but this heterogenous group is often aggregated into a single category, despite vast differences in culture, socioeconomic status, education, and access to care among subgroups. There remains a significant knowledge gap in HCC outcomes among different subgroups of API. The Surveillance, Epidemiology, and End Results (SEER) database was accessed, and site/ICD codes were used to identify HCC patients during 2010-2019 who were API ethnicity. Data collected: demographics, socioeconomic status, tumor characteristics, treatment, and survival. Subgroup analyses were performed among different Asian ethnicities in a secondary analysis. 8,249 patients were identified/subdivided into subgroups of Asian ethnicities and Other Pacific Islanders (NHOPI) groups. The median age was 65 years for Asians and 62 years for NHOPI (p < 0.01), and significant differences were found in income (p < 0.01). A higher proportion of NHOPI lived in rural areas compared to Asians (8.1 vs. 1.1%, p < 0.01). There were no statistically significant differences in tumor size, stage, pre-treatment AFP level, or surgical treatments between the two groups. However, Asians had higher overall median survival than NHOPI (20 months v 12 months, p < 0.01). Secondary analyses among different subgroups of Asian ethnicities revealed significant differences in tumor size and staging, surgical resection, transplant rates, and median survival. While API had similar tumor characteristics and treatment, Asians had much higher survival than NHOPI. Socioeconomic differences and access to care may contribute to these differences. This study also found significant survival disparities within API ethnicities.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.