肿瘤的发生和发展不仅取决于生化信号的复杂调控，还受到肿瘤微环境中的生物力学因素的影响。随着表观遗传学理论的发展，单纯从基因遗传角度上探究生物力学刺激对肿瘤进展的调控已不能完全阐明肿瘤发生机制，而从表观遗传角度上探究生物力学刺激对肿瘤进展的调控仍处于起步阶段。因此，整合现有的相关研究和进行潜在探索具有特别重要的意义。本文通过表观遗传手段，整理了生物力学因素对肿瘤的调控研究，包括总结生物力学因素对肿瘤表观遗传调控模式、展示机械刺激下表观遗传调控对肿瘤进展的影响、阐释其现有应用及展望其潜力。本文旨在通过整合生物力学刺激下肿瘤表观遗传调控相关研究，展示相应的研究进展，为潜在的后续研究和临床应用提供理论基础和新思路。在生理条件下，机械因素通过表观遗传途径刺激肿瘤进展，随着表观药物和相关递送系统的发展，有望发现新的治疗策略。©2023年该作者，独家授权Springer Nature B.V.

The occurrence and development of tumors depend on a complex regulation by not only biochemical cues, but also biomechanical factors in tumor microenvironment. With the development of epigenetic theory, the regulation of biomechanical stimulation on tumor progress genetically is not enough to fully illustrate the mechanism of tumorigenesis. However, biomechanical regulation on tumor progress epigenetically is still in its infancy. Therefore, it is particularly important to integrate the existing relevant researches and develop the potential exploration. This work sorted out the existing researches on the regulation of tumor by biomechanical factors through epigenetic means, which contains summarizing the tumor epigenetic regulatory mode by biomechanical factors, exhibiting the influence of epigenetic regulation under mechanical stimulation, illustrating its existing applications, and prospecting the potential. This review aims to display the relevant knowledge through integrating the existing studies on epigenetic regulation in tumorigenesis under mechanical stimulation so as to provide theoretical basis and new ideas for potential follow-up research and clinical applications. Mechanical factors under physiological conditions stimulate the tumor progress through epigenetic ways, and new strategies are expected to be found with the development of epidrugs and related delivery systems.© 2023. The Author(s), under exclusive licence to Springer Nature B.V.