胰胆管和妇科腺癌需要更好的工具来预测临床结果。这些癌症中已经确定了潜在的预后间充质样（类似）转录组亚型。在这个系统性综述中，我们纳入了研究分子亚型并总结起源地内部和跨部位的亚型的生物学和临床特征，寻找改进分类和预后的建议。我们通过搜索PubMed和Embase中描述胰胆管或妇科腺癌中可能的间充质（类似）mRNA亚型的原始研究文章进行了筛选。限于监督聚类的研究被排除。总共包括44篇研究，涉及胆管癌、胆囊癌、壶腹癌、胰腺癌、卵巢癌和子宫内膜癌。在所有腺癌中，间充质（类似）亚型在分子和临床特征上存在重叠。包括组织切片的方法更有可能识别出与预后相关的亚型。总之，在胰胆管和妇科腺癌中，分子亚型共享生物学和临床特征。此外，在研究胆管和妇科腺癌时应该区分基质和上皮信号。版权所有 © 2023 Elsevier B.V. 发布。

Pancreato-biliary and gynecological adenocarcinomas need better tools to predict clinical outcome. Potential prognostic mesenchymal(-like) transcriptome-based subtypes have been identified in these cancers. In this systematic review, we include studies into molecular subtyping and summarize biological and clinical features of the subtypes within and across sites of origin, searching for suggestions to improve classification and prognostication. PubMed and Embase were searched for original research articles describing potential mesenchymal(-like) mRNA-based subtypes in pancreato-biliary or gynecological adenocarcinomas. Studies limited to supervised clustering were excluded. Fourty-four studies, discussing cholangiocarcinomas, gallbladder, ampullary, pancreatic, ovarian, and endometrial adenocarcinomas were included. There was overlap in molecular and clinical features in mesenchymal(-like) subtypes across all adenocarcinomas. Approaches including microdissection were more likely to identify prognosis-associating subtypes. To conclude, molecular subtypes in pancreato-biliary and gynecological adenocarcinomas share biological and clinical characteristics. Furthermore, separation of stromal and epithelial signals should be applied in future studies into biliary and gynecological adenocarcinomas.Copyright © 2023. Published by Elsevier B.V.