组氨酸三联核苷酸结合蛋白2（HINT2）是组氨酸三联蛋白超家族中的二聚体蛋白，主要在肝脏、胰腺和肾上腺中表达，并位于线粒体中。HINT2结合核苷酸并催化核苷酸底物的水解。此外，HINT2还被确定为多种生物过程的关键调节因子，包括线粒体依赖性细胞凋亡、线粒体蛋白乙酰化和类固醇合成等。基因操作为我们提供了对HINT2在许多过程中的生理作用的新见解，例如抑制癌症进展、调节肝脏脂质代谢和对心血管系统的保护作用。本综述概述了HINT2的背景和功能。此外，它总结了HINT2与人类恶性肿瘤、肝代谢疾病和心血管疾病之间相关性的研究进展，并试图提供新的研究方向，揭示HINT2作为人类疾病对抗目标的治疗价值。版权所有©2023 Elsevier Inc. 发布。

Histidine triad nucleotide-binding protein 2 (HINT2) is a dimeric protein that belongs to the histidine triad protein superfamily, predominantly expressed in the liver, pancreas, and adrenal gland, and localised to the mitochondrion. HINT2 binds nucleotides and catalyses the hydrolysis of nucleotidyl substrates. Moreover, HINT2 has been identified as a key regulator of multiple biological processes, including mitochondria-dependent apoptosis, mitochondrial protein acetylation, and steroidogenesis. Genetic manipulation has provided new insights into the physiological roles of HINT2 in several processes, such as inhibition of cancer progression, regulation of hepatic lipid metabolism, and protective effects on the cardiovascular system. The current review outlines the background and functions of HINT2. In addition, it summarises research progress on the correlation between HINT2 and human malignancies, hepatic metabolic diseases, and cardiovascular diseases, with an attempt to provide new research directions emerging in this field and to unveil the therapeutic value of HINT2 as a target in the combat of human diseases.Copyright © 2023. Published by Elsevier Inc.