类遗残物1（VGLL1）是最近发现的促增殖和侵袭的驱动因素，在许多侵袭性人类恶性肿瘤中表达，并与恶性预后强烈相关。VGLL1基因编码一个共转录激活剂，其在河马通路中的关键激活剂显示出引人注目的结构相似性，提供了重要的功能作用线索。VGLL1以类似于YAP1的方式结合TEADs，但似乎激活了一组不同的下游基因靶点。在哺乳动物中，VGLL1表达几乎仅限于胎盘滋养层细胞，这些细胞与癌症共有许多特点。由于其作为肿瘤进展的驱动因素的作用，VGLL1已成为潜在抗癌治疗的一个关注点。在本综述中，我们从进化的角度讨论VGLL1，对比其在胎盘和肿瘤发展中的作用，总结目前关于信号通路如何调节VGLL1功能的知识，并讨论针对VGLL1治疗的潜在方法。Copyright © 2023. Elsevier B.V. 发布。

Vestigial-like 1 (VGLL1) is a recently discovered driver of proliferation and invasion that is expressed in many aggressive human malignancies and is strongly associated with poor prognosis. The VGLL1 gene encodes for a co-transcriptional activator that shows intriguing structural similarity to key activators in the hippo pathway, providing important clues to its functional role. VGLL1 binds to TEADs in an analogous fashion to YAP1 but appears to activate a distinct set of downstream gene targets. In mammals, VGLL1 expression is found almost exclusively in placental trophoblasts, cells that share many hallmarks of cancer. Due to its role as a driver of tumor progression, VGLL1 has become a target of interest for potential anticancer therapies. In this review, we discuss VGLL1 from an evolutionary perspective, contrast its role in placental and tumor development, summarize the current knowledge of how signaling pathways can modulate VGLL1 function, and discuss potential approaches for targeting VGLL1 therapeutically.Copyright © 2023. Published by Elsevier B.V.