颅底恶性肿瘤的质子放疗：放疗及并发症的成像考虑。
Proton Radiotherapy for Skull-Base Malignancies: Imaging Considerations of Radiotherapy and Complications.
发表日期：2023 Mar 31
作者：
Adam L Holtzman, Roi Dagan, William M Mendenhall
来源：
PHYSICAL THERAPY & REHABILITATION JOURNAL
摘要：
质子治疗（PT）是一种高度一致的外部束流放射治疗形式，用于减轻放疗后的急性和迟发作用。治疗适应症包括良性和恶性的颅底和中枢神经系统病理。研究已经表明，PT在最小化神经认知衰退和降低低中枢神经系统坏死率的同时呈现出有前途的成果。生物学优化的未来方向和进展可能提供超越粒子剂量学物理属性的额外益处。版权所有©2023 Elsevier Inc.。
Proton therapy (PT) is a form of highly conformal external-beam radiotherapy used to mitigate acute and late effects following radiotherapy. Indications for treatment include both benign and malignant skull-base and central nervous system pathologies. Studies have demonstrated that PT shows promising results in minimizing neurocognitive decline and reducing second malignancies with low rates of central nervous system necrosis. Future directions and advances in biologic optimization may provide additional benefits beyond the physical properties of particle dosimetry.Copyright © 2023 Elsevier Inc. All rights reserved.