肺泡囊虫肺炎感染在使用帕博利珠单抗治疗肺腺癌过程中的病例报告。
Pneumocystis Pneumonia Infection Following the Initiation of Pembrolizumab Therapy for Lung Adenocarcinoma: A Case Report.
发表日期:2023 Mar 31
作者:
Toshiyuki Sumi, Kazuya Takeda, Haruhiko Michimata, Daiki Nagayama, Yuta Koshino, Hiroki Watanabe, Yuichi Yamada, Kentaro Kodama, Hirotaka Nishikiori, Hirofumi Chiba
来源:
Immunity & Ageing
摘要:
Pneumocystis肺炎 (PCP) 是一种机会性感染,肺部放射影学显示玻璃影。间质性肺病是免疫检查点抑制剂 (ICI) 治疗常见的不良反应之一,然而,ICI治疗相关PCP感染的报道很少。77岁的男性肺腺癌患者在接受pembrolizumab治疗2周后因呼吸困难住院。胸部CT显示两肺叶玻璃状浸润。因此,诊断为PCP感染,开始使用皮质类固醇和磺胺甲氧嘧啶-甲氧苄氨嘧啶治疗。治疗后,患者的病情迅速好转。这份报告表明ICI治疗可能会导致PCP感染。
Pneumocystis pneumonia (PCP) is an opportunistic infection that presents a ground-glass appearance in the lungs on chest radiography. Interstitial lung disease is a commonly reported adverse effect of immune checkpoint inhibitor (ICI) treatment; however, there are few reports of ICI treatment-associated PCP infection. A 77-year-old man with lung adenocarcinoma was administered pembrolizumab and hospitalized for dyspnea 2 weeks after treatment. Chest computed tomography showed bilateral ground-glass opacities in all lung lobes. PCP was therefore diagnosed, and steroids and sulfamethoxazole-trimethoprim were initiated. Following treatment, the patient's condition improved promptly. This report suggests that ICI treatment can cause PCP infection.