我们旨在研究血清层粘连蛋白（LN）水平与房颤（AF）患者心功能的相关性及其在院中预后的预测价值。本研究纳入2019年1月至2021年1月南通大学附属第二医院295名房颤患者。根据纽约心脏协会（NYHA）功能分类将患者分为三组（I-II、III和IV），LN水平随NYHA分级增加而增加（P < 0.05）。Spearman相关分析显示LN与NT-proBNP呈正相关（r = 0.527，P <0.001）。患者中有36例发生住院期间重大不良心脏事件（MACEs），其中30例急性心力衰竭，5例恶性心律失常，1例中风。LN预测住院期间MACEs的ROC曲线下面积为0.815（95％CI：0.740-0.890，P < 0.001）。多元逻辑回归分析显示LN可能是MACEs独立的预测因子（比值比：1.009，95％置信区间：1.004-1.015，P = 0.001）。总之，LN可能成为评估房颤患者心功能严重程度和预测住院期间预后的潜在生物标志物。

We aimed to investigate the correlation between serum laminin (LN) levels and cardiac function in patients with atrial fibrillation (AF) and its predictive value for in-hospital prognosis. This study included 295 patients with AF who were admitted to the Second Affiliated Hospital of Nantong University from January 2019 to January 2021. The patients were divided into three groups according to the New York Heart Association (NYHA) functional classification (I-II, III, and IV); the LN levels increased with increasing NYHA class (P < 0.05). Spearman's correlation analysis revealed a positive correlation between LN and NT-proBNP (r = 0.527, P < 0.001). Of the patients, 36 had in-hospital major adverse cardiac events (MACEs), of whom 30 had acute heart failure, 5 had malignant arrhythmias, and one had stroke. The area under the ROC curve for predicting the in-hospital MACEs by LN was 0.815 (95% CI: 0.740-0.890, P < 0.001). Multivariate logistic regression analysis revealed that LN could be an independent predictor of in-hospital MACEs (odds ratio: 1.009, 95% confidence interval: 1.004-1.015, P = 0.001). In conclusion, LN may serve as a potential biomarker to evaluate the severity of cardiac function and predict in-hospital prognosis in AF patients.