语音障碍是舌鳞状细胞癌（TSCC）患者中常见的功能障碍，可能会降低他们的生活质量。目前很少有多维度和长期评估TSCC患者语音功能的研究。本研究为期3年，自2018年1月至2021年3月在中国中山大学口腔医院进行。本研究共有92例（男性53例，年龄范围24-77岁）被诊断为TSCC的患者参加。使用语音障碍指数问卷和声学参数，从手术前到术后一年对语音功能进行评估。通过线性混合效应模型来分析术后语音障碍的危险因素。采用t检验或Mann-Whitney U检验来分析危险因素影响下声学参数的不同，以确定TSCC患者语音障碍的病理生理机制。手术前的语音障碍发生率为58.7％，手术后增加至91.4％。较高的 T 分期（P < 0.001）和较大的舌切除范围（P=0.002）是术后语音障碍的危险因素。在声学参数中，随着 T 分期的升高（P = 0.021）和舌切除范围的扩大（P = 0.009），F2/i 明显降低，表明舌在前后方向上的移动受限。随访期间声学参数分析显示，部分或全部舌切除的患者的 F1 和 F2 没有显着变化。TSCC患者的语音障碍是普遍存在且持久的。较小的残余舌体积会导致较差的与语音相关的生活质量，这表明术后恢复舌的长度和加强舌伸展可能非常重要。 ©2023作者。

Speech disorders are common dysfunctions in patients with tongue squamous cell carcinoma (TSCC) that can diminish their quality of life. There are few studies with multidimensional and longitudinal assessments of speech function in TSCC patients.This longitudinal observational study was conducted at the Hospital of Stomatology, Sun Yat-sen University, China, from January 2018 to March 2021. A cohort of 92 patients (53 males, age range: 24-77 years) diagnosed with TSCC participated in this study. Speech function was assessed from preoperatively to one year postoperatively using the Speech Handicap Index questionnaire and acoustic parameters. The risk factors for postoperative speech disorder were analyzed by a linear mixed-effects model. A t test or Mann‒Whitney U test was applied to analyze the differences in acoustic parameters under the influence of risk factors to determine the pathophysiological mechanisms of speech disorders in patients with TSCC.The incidence of preoperative speech disorders was 58.7%, which increased up to 91.4% after surgery. Higher T stage (P＜0.001) and larger range of tongue resection (P = 0.002) were risk factors for postoperative speech disorders. Among the acoustic parameters, F2/i/decreased remarkably with higher T stage (P = 0.021) and larger range of tongue resection (P = 0.009), indicating restricted tongue movement in the anterior-posterior direction. The acoustic parameters analysis during the follow-up period showed that F1 and F2 were not significantly different of the patients with subtotal or total glossectomy over time.Speech disorders in TSCC patients is common and persistent. Less residual tongue volume led to worse speech-related QoL, indicating that surgically restoring the length of the tongue and strengthening tongue extension postoperatively may be important.© 2023. The Author(s).