Interleukin-25 (IL-25), 也称为IL-17E，是属于IL-17家族的一种细胞因子。 IL-25由Th2细胞和各种上皮细胞丰富表达。 在细胞损伤或组织损伤时，IL-25是产生的警报信号，通过与IL-17RA和IL-17RB受体相互作用来激活免疫细胞。 IL-25与IL-17RA / IL-17RB复合物的结合不仅启动和维持2型免疫，还通过各种信号途径调节其他免疫细胞（例如，巨噬细胞和肥大细胞）。已经有充分文献证明，IL-25在过敏性疾病（例如哮喘）的发展中扮演着重要角色。然而，IL-25在其他疾病的发病机制和作用仍不清楚。本综述提供了IL-25在癌症、过敏性疾病和自身免疫性疾病中作用的最新证据。此外，我们讨论了IL-25介导疾病病理的未答复关键问题，这将为该细胞因子的靶向治疗提供新的见解。©2023. 作者。

Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction with IL-17RA and IL-17RB receptors. The binding of IL-25 to IL-17RA/IL-17RB complex not only initiates and maintains type 2 immunity but also regulates other immune cells (e.g., macrophages and mast cells) via various signaling pathways. It has been well-documented that IL-25 is critically involved in the development of allergic disorders (e.g., asthma). However, the roles of IL-25 in the pathogenesis of other diseases and the underlying mechanisms are still unclear. This review presents current evidence on the roles of IL-25 in cancers, allergic disorders, and autoimmune diseases. Moreover, we discuss the unanswered key questions underlying IL-25-mediated disease pathology, which will provide new insights into the targeted therapy of this cytokine in clinical treatment.© 2023. The Author(s).