除了其代谢活动外，现在清楚地知道肝脏还有许多不同的免疫细胞类型来控制组织稳态。其中最重要的是先天样T淋巴细胞，包括自然杀伤T（NKT）和粘膜相关的先天性T（MAIT）细胞，它们是一种具有先天特征的专门T细胞群体，表达半不变T细胞受体具有非肽抗原特异性。作为主要的肝脏居民，先天样T细胞已与肝脏免疫耐受以及许多肝脏疾病有关。在这里，我们将重点介绍NKT和MAIT细胞的生物学以及它们在最终导致肝细胞癌的慢性炎症性疾病过程中的作用。版权所有 © 2023 Papanastasatou和Verykokakis。

In addition to its metabolic activities, it is now clear that the liver hosts a number of diverse immune cell types that control tissue homeostasis. Foremost among these are innate-like T lymphocytes, including natural killer T (NKT) and mucosal-associated innate T (MAIT) cells, which are a population of specialized T cells with innate characteristics that express semi-invariant T cell receptors with non-peptide antigen specificity. As primary liver residents, innate-like T cells have been associated with immune tolerance in the liver, but also with a number of hepatic diseases. Here, we focus on the biology of NKT and MAIT cells and how they operate during the course of chronic inflammatory diseases that eventually lead to hepatocellular carcinoma.Copyright © 2023 Papanastasatou and Verykokakis.