N6-甲基腺嘌呤（m6A）甲基化是真核生物中最普遍的mRNA修饰方式，它被定义为在甲基转移酶的存在下对RNA六个腺嘌呤（A）碱基的氮原子进行甲基化。甲基转移酶样蛋白3（Mettl3）是m6A甲基转移酶的组分之一，在m6A甲基化中发挥决定性催化作用。最近的研究证实，m6A与广泛的生物过程有关，它显著影响妇科肿瘤患者的疾病进展和预后，其中Mettl3的作用不可忽视。Mettl3参与了许多病理生理学功能，如胚胎发育、脂肪积累和肿瘤进展。此外，Mettl3可能作为治疗妇科恶性肿瘤的潜在靶点，因此，它可能使患者受益并延长生存期。然而，有必要进一步研究Mettl3在妇科恶性肿瘤中的作用及机制。本文综述了Mettl3在妇科恶性肿瘤中的最新进展，希望为进一步的研究提供参考。版权所有©2023 Zhang and Zhang。

N6-methyladenosine (m6A) methylation is the most prevalent mRNA modification in eukaryotes, and it is defined as the methylation of nitrogen atoms on the six adenine (A) bases of RNA in the presence of methyltransferases. Methyltransferase-like 3 (Mettl3), one of the components of m6A methyltransferase, plays a decisive catalytic role in m6A methylation. Recent studies have confirmed that m6A is associated with a wide spectrum of biological processes and it significantly affects disease progression and prognosis of patients with gynecologic tumors, in which the role of Mettl3 cannot be ignored. Mettl3 is involved in numerous pathophysiological functions, such as embryonic development, fat accumulation, and tumor progression. Moreover, Mettl3 may serve as a potential target for treating gynecologic malignancies, thus, it may benefit the patients and prolong survival. However, there is a need to further study the role and mechanism of Mettl3 in gynecologic malignancies. This paper reviews the recent progression on Mettl3 in gynecologic malignancies, hoping to provide a reference for further research.Copyright © 2023 Zhang and Zhang.