幽门螺杆菌是引起胃炎、消化性溃疡和胃癌的突出原因。它自然地寄居在胃窦粘液层和黏膜上皮细胞的表面，不仅被高黏度的黏液层包围以防止药物分子与细菌接触，还被众多的胃酸和胃蛋白酶包围，使抗菌药物失去活性。生物材料具有高性能的生物相容性和生物特异性，并与H.pylori根除紧密相关，是最有前途的方向之一。为了全面总结该领域的研究进展，我们在SCI数据库中筛选了101篇文章，并利用VOSviewer和CiteSpace进行了文献计量学调查，以建立出版物、国家、机构、作者和相关主题之间的关系。关键词分析表明，纳米颗粒、金属材料、脂质体和聚合物等生物材料被最频繁地使用。根据其组成材料和结构特点，生物材料在除H. pylori方面展现了丰富的前景，包括延长药物输送时间，避免药物失活，定向响应和处理药物抗性。此外，我们还概述了有关高性能生物材料在H.pylori根除方面的挑战和未来研究展望，以最近的研究为基础。版权 © 2023 Shu, Xu, He, Xu, Zhou, Cai and Zhu.

Helicobacter pylori is a prominent cause of gastritis, peptic ulcer, and gastric cancer. It is naturally colonized on the surface of the mucus layer and mucosal epithelial cells of the gastric sinus, surrounded not only by mucus layer with high viscosity that prevents the contact of drug molecules with bacteria but also by multitudinous gastric acid and pepsin, inactivating the antibacterial drug. With high-performance biocompatibility and biological specificity, biomaterials emerge as promising prospects closely associated with H. pylori eradication recently. Aiming to thoroughly summarize the progressing research in this field, we have screened 101 publications from the web of science database and then a bibliometric investigation was performed on the research trends of the application of biomaterials in eradicating H. pylori over the last decade utilizing VOSviewer and CiteSpace to establish the relationship between the publications, countries, institutions, authors, and most relevant topics. Keyword analysis illustrates biomaterials including nanoparticles (NPs), metallic materials, liposomes, and polymers are employed most frequently. Depending on their constituent materials and characterized structures, biomaterials exhibit diverse prospects in eradicating H. pylori regarding extending drug delivery time, avoiding drug inactivation, target response, and addressing drug resistance. Furthermore, we overviewed the challenges and forthcoming research perspective of high-performance biomaterials in H. pylori eradication based on recent studies.Copyright © 2023 Shu, Xu, He, Xu, Zhou, Cai and Zhu.