我们报告了在膜性肾病患者的肾小球毛细血管壁上检测到了神经表皮生长因子样1(NELL-1)和免疫球蛋白G4(IgG4)。这导致了发现一位68岁男性食管鳞状细胞癌(ESCC)手术后早期复发的情况。此外，ESCC癌组织样本中也检测到了NELL-1。此外，与先前的报道和另一位年龄相仿的NELL-1阴性膜性肾病男性相比，血清IgG4百分比似乎更高。因此，在肾活检中发现NELL-1应引起详细的恶性肿瘤检查，特别是伴有IgG4优势的情况。 ©2022作者。由牛津大学出版社代表ERA出版。

We reported the detection of neural epidermal growth factor-like 1 (NELL-1) and immunoglobulin G4 (IgG4) on glomerular capillary wall in membrane nephropathy (MN), which led to the discovery of early post-operative recurrence of esophageal squamous cell cancer (ESCC) in a 68-year-old man. Further, NELL-1 was also identified in the cancerous tissue sampled by esophagoscope. Moreover, serum IgG4 percentage seemed to be higher when comparing with both previous reports and another age-matched male with NELL-1-negative MN upon fully recovered ESCC. Therefore, the finding of NELL-1 in a renal biopsy should trigger a detailed workup in search of malignancy, especially with concomitant IgG4 dominance.© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.