RNA修饰在肝细胞癌的发生和发展中发挥着重要的作用。最为明确的RNA修饰是m6A，而其他种类的RNA修饰在肝细胞癌中尚未得到完全研究。在本研究中，我们调查了100个带有与癌症相关的8种不同类型的RNA修饰的RNA修饰调节因子在HCC中的作用。表达分析显示，近90％的RNA调节因子在肿瘤中的表达显着高于正常组织。通过一致聚类，我们确定了两个具有不同生物特征、免疫微环境和预后模式的聚类。构建了一个RNA修饰分数（RMScore），将患者分为高风险组和低风险组，显示了显著不同的预后。此外，包括临床病理特征和RMScore的预测模型能够很好地预测肝细胞癌患者的生存。本研究表明8种RNA修饰在HCC中的重要作用，并开发了一个RMScore，这将是预测HCC患者预后的新方法。Copyright © 2023 Qin，Jin和Zou。

RNA modification plays important role in the occurrence and development of hepatocellular carcinoma. The best characterized RNA modification is m6A, while other kinds of RNA modifications have not been fully investigated in hepatocellular carcinoma (HCC). In the current study, we investigated the roles of one hundred RNA modification regulators belonging to eight different types of cancer-related RNA modifications in HCC. Expression analysis revealed that nearly 90% RNA regulators exhibited significantly higher expression in tumors than normal tissues. By consensus clustering, we identified two clusters with distinct biological characteristics, immune microenvironment, and prognostic pattern. An RNA modification score (RMScore) was constructed and stratified patients into high- and low-risk group, which showed significantly different prognosis. Moreover, a nomogram including clinicopathologic features and the RMScore could well predict the survival in HCC patients. This study indicated the important role of eight types of RNA modification in HCC and develop a RMScore, which will be a new method to forecast the prognosis of HCC patients.Copyright © 2023 Qin, Jin and Zou.