肾细胞癌（RCC）对人类健康构成严重威胁，急需一种能够快速区分临床实践中人类正常肾组织（NRT）和RCC的方法，以进行准确检测。NRT和RCC组织细胞形态的显著差异在生物电阻抗分析（BIA）中具有区分两种不同人类组织的潜力。该研究旨在通过比较10 Hz至100 MHz范围内的介电性能，实现这种区分。在严格控制的环境（37℃，90%湿度）下，测量了69例人类正常和癌变肾组织的介电性能。除阻抗参数（电阻率，电导率和相对介电常数）外，还比较了从Cole曲线中提取的特征参数。此外，还使用了一种新的指标，区分系数（DC），以获取RCC和NRT之间的最佳区分频率。就阻抗参数而言，在低频(<1 kHz)时，RCC电导率比NRT大约1.4倍，且其相对介电常数也显著较高(p < 0.05)。就特征参数而言，发现了两个特征频率（14.1 ± 1.1 kHz和1.16 ± 0.13 MHz）用于NRT，而仅一个频率用于RCC（0.60 ± 0.05 MHz）。还观察到RCC和NRT之间低频电阻值（R0）的显著差异(p < 0.05)。至于新指标DC，介电常数DC在100 Hz以下和14 kHz左右均大于1。这些发现进一步证实了区分RCC和NRT的可行性，并为继续临床研究BIA检测手术边缘提供了数据。 作者版权所有 © 2023 Wang，Shi，Cao，Dong和Yang。

Renal cell carcinoma (RCC) poses a serious threat to human health, which urgently requires a method that can quickly distinguish between human normal renal tissue (NRT) and RCC for the purpose of accurate detection in clinical practice. The significant difference in cell morphology between NRT and RCC tissue underlies the great potential of the bioelectrical impedance analysis (BIA) to distinguish two types of human tissues. The study aims to achieve such discrimination through comparison of their dielectric properties within the frequency range from 10 Hz to 100 MHz. The dielectric properties of 69 cases of human normal and cancer renal tissue were measured 15 min after tissue isolation in a strictly controlled environment (37°C, 90% humidity). In addition to the impedance parameters (resistivity, conductivity and relative permittivity), the characteristic parameters extracted from the Cole curve were also compared between NRT and RCC. Furthermore, a novel index, distinguishing coefficient (DC), was used to obtain the optimal frequency for discrimination between NRT and RCC. In terms of impedance parameters, the RCC conductivity at low frequencies (<1 kHz) was about 1.4 times as large as that of NRT, and its relative permittivity was also significantly higher (p < 0.05). In terms of characteristic parameters, two characteristic frequencies (14.1 ± 1.1 kHz and 1.16 ± 0.13 MHz) were found for NRT while only one for RCC (0.60 ± 0.05 MHz). A significant difference of low-frequency resistance (R0) between RCC and NRT was also observed (p < 0.05). As for the new index DC, relative permittivity DCs below 100 Hz and at around 14 kHz were both greater than 1. These findings further confirm the feasibility of discrimination between RCC and NRT and also provide data in favor of further clinical study of BIA to detect the surgical margins.Copyright © 2023 Wang, Shi, Cao, Dong and Yang.