宫颈癌（CC）是世界范围内女性第四常见的癌症类型，被认为是导致肿瘤相关死亡和恶性瘤的主要原因。作为表观遗传控制中复杂体的一部分，染色质盒（CBX）家族蛋白质已被发现在防止分化和增加增殖方面在恶性肿瘤的生长中发挥作用。在这里，通过彻底的调查，我们调查了患有CC的患者中CBX的表达、预后意义和免疫浸润。使用TIMER、Metascape、STRING、GeneMANIA、cBioPortal、UALCAN、The Human Protein Atlas、Gene Expression Profiling Interactive Analysis（GEPIA）和Oncomine，检查了患有CC的患者中CBX的差异表达、临床病理参数、免疫细胞浸润、富集分析、遗传改变和预后价值。在CC组织中，CBX 2/3/4/5和CBX 8的表达水平明显较高，而CBX 6/7的表达水平较低。在CC中，CBX 5/6/8启动子具有较高的甲基化水平。CBX 2/6/8的表达与病理分期有关。观察到不同表达CBX基因的37％突变率。此外，CBX的表达与免疫细胞浸润如T细胞CD4+、巨噬细胞、中性粒细胞、B细胞、T细胞CD8+和树突状细胞之间存在强相关性。研究发现CBX家族成员可能是CC患者的治疗靶点，并在CC肿瘤的发展中发挥重要作用。

Cervical cancer (CC) is the fourth most prevalent type of cancer in women worldwide and it is considered the leading cause of tumor-related death and malignancy. As part of complexes involved in epigenetic control, the proteins of the chromobox (CBX) family have been found to have a role in the growth of malignancies by preventing differentiation and increasing proliferation. Here, by a thorough investigation, we investigated the expression, prognostic significance, and immune infiltration of CBX in patients with CC.Differential expression, clinicopathological parameters, immune cell infiltration, enrichment analysis, genetic alteration, and prognostic value of CBXs in patients with CC were examined using TIMER, Metascape, STRING, GeneMANIA, cBioPortal, UALCAN, The Human Protein Atlas, Gene Expression Profiling Interactive Analysis (GEPIA), and Oncomine.In CC tissues, CBX 2/3/4/5 and CBX 8 expression levels were considerably higher, whereas CBX 6/7 expression levels were lower. In CC, the CBX 5/6/8 promoters have elevated levels of methylation. The expression of CBX 2/6/8 and the pathological stage were connected. A 37% mutation rate of the differentially expressed CBX genes was observed. Also, there was a strong correlation of the CBXs expression with immune cell infiltration, such as T CD4+ cells, macrophages, neutrophils, B cells, T CD8+ cells, and dendritic cells.The investigation discovered that members of the CBXs family may be therapeutic targets for CC patients and may play significant roles in the development of CC tumors.