越来越多的证据表明肠道微生物组（IM）与结直肠癌（CRC）密切相关。为了探究IM/CRC领域的科学产出、确定高引用论文、探索研究热点和趋势，我们进行了文献计量和可视化分析。于2022年10月17日实施了关于IM/CRC研究（2012-2021）的文献检索。 IM和CRC领域的术语在标题（TI）、摘要（AB）和作者关键词（AK）中进行了搜索。主要信息从Web of Science Core Collection（WoSCC）中提取。使用R包的Biblioshiny和VOSviewer进行数据可视化。共检索到1725篇与IM/CRC相关的论文。自2012年至2021年，IM/CRC的发表量迅速增长。中国和美国在该领域的发表中处于领先地位，并对IM/CRC研究做出了最重要的贡献。上海交通大学和哈佛大学是最具生产力的机构。高产作者为俞俊和方京元。《分子科学国际期刊》发表的论文最多，而《Gut》的引用最多。历史引用分析显示了IM/CRC研究的发展演变。使用关键词聚类分析突出了当前状态和热点。热门话题包括IM对肿瘤发生的影响、IM对CRC治疗的影响、IM在CRC筛查中的作用、IM参与CRC的机制以及IM对CRC管理的调节。一些主题，如化疗、免疫疗法、Fusobacterium nucleatum和短链脂肪酸可能成为未来IM/CRC研究的焦点。该研究评估了IM/CRC研究的全球科学产出及其定量特征，确定了一些重要的论文，收集了IM/CRC研究的状态和趋势信息，这可能塑造了学者和从业人员未来的研究方向。版权所有 © 2023 Yang、Hao、Ye和Zhang。

Increasing evidence has shown that the intestinal microbiome (IM) is highly linked to colorectal cancer (CRC). To investigate scientific output, identify highly cited papers, and explore research hotspots and trends in the field of IM/CRC, we conducted a bibliometric and visualized analysis.A bibliographic search regarding IM/CRC research (2012-2021) was implemented on October 17, 2022. The terms attached to IM and CRC were searched for in the titles (TI), abstracts (AB), and author keywords (AK). The main information was extracted from the Web of Science Core Collection (WoSCC). Biblioshiny from R packages and VOSviewer were used for data visualization.A total of 1725 papers related to IM/CRC were retrieved. Publications on IM/CRC have grown rapidly from 2012 to 2021. China and the United States were in the leading position for publications in this field and made the most significant contributions to IM/CRC research. Shanghai Jiao Tong University and Harvard University were the most productive institutions. The high-yield authors were Yu Jun and Fang Jing Yuan. The International Journal of Molecular Sciences published the most papers, whereas Gut had the most citations. Historical citation analysis showed the evolution of IM/CRC research. Current status and hotspots were highlighted using keyword cluster analysis. The hot topics include the effect of IM on tumorigenesis, the effect of IM on CRC treatment, the role of IM in CRC screening, the mechanisms of IM involvement in CRC, and IM modulation for CRC management. Some topics, such as chemotherapy, immunotherapy, Fusobacterium nucleatum and short-chain fatty acids could be the focus of IM/CRC research in the coming years.This research evaluated the global scientific output of IM/CRC research and its quantitative features, identified some significant papers, and gathered information on the status and trends of IM/CRC research, which may shape future paths for academics and practitioners.Copyright © 2023 Yang, Hao, Ye and Zhang.