Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response. (肿瘤溶解病毒调节免疫原性细胞死亡、细胞凋亡和自噬，与病毒治疗和癌症免疫反应联系在一起。)
Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response.
发表日期：2023
作者：
Yi-Ying Wu, Te-Kai Sun, Ming-Shan Chen, Muhammad Munir, Hung-Jen Liu
来源：
Cell Death & Disease
摘要：
最近的报告显示，溶瘤病毒（OVs）在癌症治疗中发挥着重要作用。溶瘤疫苗病毒（OVV）、口蹄疫病毒（VSV）、细小病毒、哺乳动物丝裂病毒（MRV）、人腺病毒、新城疫病毒（NDV）、单纯疱疹病毒（HSV）、鸟类丝裂病毒（ARV）、口疮病毒（ORFV）、灭活仙台病毒（ISV）、肠道病毒和可可萨基病毒等OVs的感染通过多种不同和动态的途径，在免疫治疗中提供独特的机会。本篇综述重点介绍了OVs介导的病毒治疗机制以及其对免疫原性细胞死亡（ICD）、细胞凋亡、自噬和免疫系统调节的影响。版权所有 © 2023 Wu、Sun、Chen、Munir和Liu。
Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus, Newcastle disease virus (NDV), herpes simplex virus (HSV), avian reovirus (ARV), Orf virus (ORFV), inactivated Sendai virus (ISV), enterovirus, and coxsackievirus offer unique opportunities in immunotherapy through diverse and dynamic pathways. This mini-review focuses on the mechanisms of OVs-mediated virotherapy and their effects on immunogenic cell death (ICD), apoptosis, autophagy and regulation of the immune system.Copyright © 2023 Wu, Sun, Chen, Munir and Liu.