将空间分辨的多重蛋白质分析推向临床肿瘤学。
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology.
发表日期：2023 Apr 03
作者：
Maryam Pourmaleki, Nicholas D Socci, Travis J Hollmann, Ingo K Mellinghoff
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS
摘要：
癌症治疗的转变，从广谱细胞毒性药剂向“个性化”的治疗转变，旨在针对每个患者肿瘤中特定的改变，需要定量和对生物样品友好的诊断病理学方法。新颖的多重抗体基础成像技术可以测量完整肿瘤切片中超过60种蛋白质的单细胞表达，并有望在临床肿瘤学中发挥作用。©2023作者；由美国癌症研究协会出版。
The shift in cancer therapy from broadly cytotoxic agents toward "personalized" treatments that target specific alterations in each patient's tumor requires diagnostic pathology approaches that are quantitative and biospecimen-friendly. Novel multiplexed antibody-based imaging technologies can measure single-cell expression of over 60 proteins in intact tumor sections and hold promise for clinical oncology.©2023 The Authors; Published by the American Association for Cancer Research.