HPV整合可以驱动病毒-宿主细胞外染色体DNA在肿瘤中形成。
HPV Integration Can Drive the Formation of Virus-Host Extrachromosomal DNA in Tumors.
发表日期：2023 Apr 03
作者：
Alison A McBride, Elizabeth A White
来源：
Cancer Discovery
摘要：
人类乳头瘤病毒（HPV）阳性癌细胞含有病毒和宿主DNA，并表现出明显的基因组不稳定性。在《癌症发现》杂志的这一期中，Akagi和同事描述了HPV阳性细胞中病毒-宿主DNA分子极其复杂的构成，提供了多种融合和染色体外的病毒-宿主混合DNA证据，有潜力推动克隆演化。请参阅Akagi等人的相关文章，第910页（4）。©2023年美国癌症研究协会。
Human papillomavirus (HPV)-positive cancer cells contain virus and host DNA and exhibit marked genome instability. In this issue of Cancer Discovery, Akagi and colleagues characterize the remarkably complex landscape of virus-host DNA molecules in HPV-positive cells, providing evidence for diverse integrated and extrachromosomal virus-host hybrid DNAs with the potential to drive clonal evolution. See related article by Akagi et al., p. 910 (4).©2023 American Association for Cancer Research.